Marion Gordon

Associate Professor
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America

Professor Toxicology
Biography

Dr. Gordon received her BS in Chemistry (1973) and PhD. in the Rutgers-UMDNJ joint graduate program in Biochemistry in 1986. Dr. Gordon’s last year of graduate school was completed at Harvard Medical School in the Anatomy and Cell Biology Department, where she stayed to do post doctoral training. After a second post doctoral fellowship in the Anatomy and Cell Biology Department at Tufts Medical School she joined the faculty as an Assistant Professor, and remained there for 7 years. She came to the Ernest Mario School of Pharmacy in 1998, and is presently an Associate Professor in the Pharmacology and Toxicology Department. Dr. Gordon has been continuously funded by NIH since 1988. She teaches the PharmD students in their P1 and P2 years in the Pathophysiology and in Pharmacology I and II courses. She has served on the thesis committees of 31 graduate students, and in her laboratory she has trained 2 MD research residents, 8 medical and graduate students (2 from Tufts Medical School), 13 pharmacy students (including 2 honors research students), as well as 1 MIT and 9 Rutgers undergraduate students. She has been thesis advisor to 1 M.S. student and 3 Ph.D. students in the Joint Program in Toxicology. Dr. Gordon has served on the editorial boards for Developmental Dynamics, Anatomical Record, and on the editorial board of Matrix Biology. She currently serves on the Anterior Eye Disease Study Section of the NIH. She has been very active in the American Association of Anatomists, serving this national society as an executive officer for 5 years.

Research Intrest

Collagens, wound healing, fibrosis, corneal development, collagen pathologies, sulfur mustard injury, chemical counterterrorism

List of Publications
Zheng, R, Po, I, Mishin, V, Black, AT, Heck, DE, Laskin, DL, Sinko, PJ, Gerecke, DR, Gordon, MK, Laskin, JD et al.. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol. Appl. Pharmacol. 2013;272 (2):345-55. doi: 10.1016/j.taap.2013.06.025. PubMed PMID:23845594 PubMed Central PMC4167050
Chang, YC, Wang, JD, Hahn, RA, Gordon, MK, Joseph, LB, Heck, DE, Heindel, ND, Young, SC, Sinko, PJ, Casillas, RP et al.. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol. Appl. Pharmacol. 2014;280 (2):236-44. doi: 10.1016/j.taap.2014.07.016. PubMed PMID:25127551 PubMed Central PMC4254337
Tseng, CY, Chang, JF, Wang, JS, Chang, YJ, Gordon, MK, Chao, MW. Protective Effects of N-Acetyl Cysteine against Diesel Exhaust Particles-Induced Intracellular ROS Generates Pro-Inflammatory Cytokines to Mediate the Vascular Permeability of Capillary-Like Endothelial Tubes. PLoS ONE. 2015;10 (7):e0131911. doi: 10.1371/journal.pone.0131911. PubMed PMID:26148005 PubMed Central PMC4492618
DeSantis-Rodrigues, A, Chang, YC, Hahn, RA, Po, IP, Zhou, P, Lacey, CJ, Pillai, A, C Young, S, Flowers, RA 2nd, Gallo, MA et al.. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest. Ophthalmol. Vis. Sci. 2016;57 (4):1687-98. doi: 10.1167/iovs.15-17269. PubMed PMID:27058125 PubMed Central PMC4829087
Gordon, MK, DeSantis-Rodrigues, A, Hahn, R, Zhou, P, Chang, Y, Svoboda, KK, Gerecke, DR. The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Ann. N. Y. Acad. Sci. 2016;1378 (1):158-165. doi: 10.1111/nyas.13226. PubMed PMID:27737494 PubMed Central PMC5221489