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MOHAMMED SALMAN KHAN Biswadip Das Ekaterina M. Nestorovich Joel Caton Anil Roy Dubey Saheem Ahmad Sabrina Bhagwan Carole Ayoub Moubareck Dr.(Ms.) Neeloo Singh Sarah J. Ewing Ruchi Seth Kelly A. Grant Tobias Baskin Magdalena Bezanilla Jeffrey Blanchard Steven D. Brewer Samuel H.P. Chan Catherine Day Pamela L. Tuma Mark Banfield View More
Maolin Guo

PROFESSOR
Chemistry and Biochemistry
University of Massachusetts Dartmouth
United States of America

Professor Biochemistry
Biography

Research in this lab is in the interface between chemistry, biology and medicine. This exciting field is the foundation of modern biomedical sciences which provide molecular basis for various biomedical processes. We are using multi-disciplinary approach including molecular biology, protein chemistry, synthetic and electro-chemistry, spectroscopy (NMR, UV-vis, CD, fluorescent, etc), chromatography and X-ray crystallography to investigate the molecular basis of certain genes, proteins, metal ions and signal transduction pathways related to cancer, aging, infectious, cardiovascular diseases and neurodegenerative disorders. Our research goal is to understand the molecular basis of these biochemical processes and to develop novel strategies for diagnostics and therapeutics. 

Research Intrest

 Biochemistry and Molecular Biology, Protein Engineering, Structural Biology, Bioinorganic Chemistry & Metals in Biology and Medicine

List of Publications
ssembly of an Oxo Zirconium(IV) cluster in a protein cleft W. Zhong, D. Alexeev D, I Havey, M. Guo, D. Hunter, H. Zhu, D. Campopiano, P. Sadler, Angew. Chem. Int Ed., 2004, 43, 5914-5918
Double-strand hydrolysis of DNA by a magnesium (II) complex with diethylenetriamine. P. Yang*, R. Ren, M. Guo*, A. Song, X. Meng, C. Yuan, Q. Zhou, H. Chen, Z. Xiong, X. Gao, J. Biol. Inorg. Chem. 2004, 9, 495-506
Synergistic anion and metal binding to the ferric-ion binding protein from Neisseria gonorrheae M. Guo, I. Harvey, W. Yang, L. Coghill, D. Campopiano, J. A. Parkinson, R. MacGillivray, W. Harris, P. J. Sadler J. Biol. Chem., 2003, 278, 2490-2502
Direct assessment of the reduction potential of the [4Fe-4S]1+/0 couple of the Fe protein from Azotobacter vinelandii. M. Guo, F. Sulc, M. Ribbe, P. J. Farmer, B. K. Burgess J. Am. Chem. Soc., 2002, 124, 12100-12101
The FeMoco-deficient MoFe protein produced by a nifH-deletion strain of Azotobacter vinelandii shows unusual P-cluster features M. Ribbe, Y. Hu, M. Guo, B. Schmid, B. K. Burgess J. Biol. Chem., 2002, 277, 23469-23476
Ti(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of anticancer drug titanocene dichloride M. Guo, Z. Guo, P. J. Sadler J. Biol. Inorg. Chem., 2001, 6, 698-707
Understanding the mechanism of action of the anticancer drug titanocene dichloride: TiIVuptake and release by human serum transferrin and Ti2-hTF uptake by cancer cells M. Guo, H. Sun, H. McArdle, L. Gambling, P. J. Sadler Biochemistry, 2000, 33, 10023-10033
Stereo-selective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine M. Guo, H. Sun, S. Bihari, J. Parkinson, R. Gould, S. Parsons, P. J. Sadler Inorganic Chemistry, 2000, 39, 206-215
Competitive binding of the anticancer drug titanocene dichloride to N,N´-ethylene-bis- (o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin M. Guo and P. J. Sadler J. Chem. Soc., Dalton Trans., 2000, 7-10
Interactions of organometallic anticancer agents with nucleotides and DNA P. Yang and M. Guo Coordination Chemistry Reviews, 1999, 186, 189-211

Global Scientific Words in Biochemistry

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