MAGID ABOU-GHARBIA

Director
Moulder Center for Drug Discovery Research
Temple University
United States of America

Biography

Magid Abou-Gharbia, Ph.D., FRSC is currently the Associate Dean for Research, Laura H. Carnell Professor of Medicinal Chemistry and Director of the Moulder Center for Drug Discovery Research (MCDDR) at the School of Pharmacy, Temple University, Philadelphia, PA. He is responsible for Setting and implementing School of Pharmacy research strategies to promote the school’s research and entrepreneurial enterprise. Prior to joining Temple University in 2008, Magid spent 26 years at Wyeth Pharmaceuticals where he was senior Vice President and Head of Chemical and Screening Sciences. As Senior Vice President & Head of Chemical & Screening Sciences at Wyeth, he was responsible for overseeing and directing Wyeth chemistry and screening research efforts of 500 scientists at four US research facilities and 150 chemists in Hyderabad, India in support of drug discovery in Neuroscience, Inflammation, Women's Health/Bone, Oncology and Cardio-vascular/Metabolic Diseases therapeutic areas.

Research Intrest

Research Interests: Manipulation of synthetic approaches in the design and synthesis of biologically active agents. Methodologies included: 1, 3-dipolar cycloaddition reactions, Claisen's rearrangement, Diels-Alder reactions, chemistry of ketenes, sulfilimines, synthesis of substituted steroids. Use of receptor homology, bioisoteric replacement strategies, rational and structure-based drug design approaches Utilizing natural products as a unique resource for discovering innovation therapeutics. Applying enabling technology platforms to evaluate drug-like properties of all discovered molecules to ensure clinical effectiveness of drug candidates. Design of chemical probes in support of translation medicine.

List of Publications
Raynal NJ, Lee JT, Wang Y, Beaudry A, Madireddi P, et al. (2016) Targeting calcium signaling induces epigenetic reactivation of tumor suppressor genes in cancer. Cancer research 76:1494-505.
Saribas AS, Coric P, Hamazaspyan A, Davis W, Axman R, et al. (2016) Emerging from the unknown: structural and functional features of agnoprotein of polyomaviruses. Journal of cellular physiology 231:2115-27.
Di Meco A, Li JG, Blass BE, Abou-Gharbia M, Lauretti E, et al. (2017) 12/15-Lipoxygenase inhibition reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice. Biological psychiatry 81:92-100.

Global Scientific Words in Pharmaceutical Sciences