Lucia Y. Brown

Assistant Professor
Department of Obstetrics, Gynecology and Reproductive Scienc
University of Vermont
United States of America

Biography

Prof.Lucia Y. Brown has received her M.D. - Faculdade de Medicina de Marilia, Estado de Sao Paulo, Brasil. Currently she is working as Professor in university of vermont. He has successfully completed his Administrative responsibilities as Professor. His research has holoprosencephaly gene, Zic2 and its role in early nervous system development. Current studies with Zic2 relate to its newly discovered role in the pre-implantation blastocyst as well as in embryonic stem cells. Both transgenic and tissue culture models are currently being used to elucidate Zic2 function. A second area of research relates to the global analysis of genomic methylation and the role of genomic methylation in the developing placenta.

Research Intrest

Dr. Brown’s research interests are in the holoprosencephaly gene, Zic2 and its role in early nervous system development. Current studies with Zic2 relate to its newly discovered role in the pre-implantation blastocyst as well as in embryonic stem cells. Both transgenic and tissue culture models are currently being used to elucidate Zic2 function. A second area of research relates to the global analysis of genomic methylation and the role of genomic methylation in the developing placenta.

List of Publications
Sakurai T, Lustig M, Babiarz J, Furley AJ, Tait S, Brophy PJ, Brown SA, Brown LY, Mason CA, Grumet M. Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. The Journal of cell biology. 2001 Sep 17;154(6):1259-74.
Brown LY, Odent S, David V, Blayau M, Dubourg C, Apacik C, Delgado MA, Hall BD, Reynolds JF, Sommer A, Wieczorek D. Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination. Human Molecular Genetics. 2001 Apr 2;10(8):791-6.
Brown LY, Brown SA. Alanine tracts: the expanding story of human illness and trinucleotide repeats. TRENDS in Genetics. 2004 Jan 31;20(1):51-8.
Brown SA, Warburton D, Brown LY, Yu CY, Roeder ER, Stengel-Rutkowski S, Hennekam R, Muenke M. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired. Nature genetics. 1998 Oct 1;20(2).