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Leslie Kean

Associate Professor
Pediatrics
Fred Hutchinson Cancer Rearch Center
United States of America

Professor Pediatrics
Biography

Dr. Leslie Kean is the Ben Towne Center's associate director. She joined the center in summer 2013 from Emory University. Her research focuses on improving how animal models tolerate transplanted immune cells. This could ultimately improve the odds that immunotherapy, which uses transplanted T cells, is successful in pediatric patients. Kean received her MD/PhD from Emory University and completed her postdoctoral research, residency and fellowship in pediatrics and pediatric hematology-oncology in at Emory University Hospitals and the Aflac Cancer Center and Blood Disorders Service at Children's Healthcare of Atlanta.

Research Intrest

immune recognition and immune tolerance.

List of Publications
Nickel RS, Osunkwo I, Garrett A, Robertson J, Archer DR, Promislow DE, Horan JT, Hendrickson JE, Kean LS, "Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy." British journal of haematology 169.4 (2015 May): 574-83.
Mavigner M, Watkins B, Lawson B, Lee ST, Chahroudi A, Kean L, Silvestri G, "Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant." PLoS pathogens 10.9 (2014 Sep): e1004406.
Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS, "CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis." Blood 123.12 (2014 Mar 20): 1967-9.
Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS, "In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 19.11 (2013 Nov): 1638-49.
Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS, "Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection." PloS one 8.8 (2013): e71221.
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