Find Experts

Experts in Cardiology
Prof. Dr. Mohammed Ibrahim Abdel Magued Arunima Sengupta Dr. Naibedya Chattopadhyay David J. Burritt Anthony Emekalam Sunil Baldwa Michael J. Miller Hiroko Beck Vivian M. Abascal David H Adams Susan Zieman Ismayil Ahmet Mingyi Wang ASHEQUL ISLAM Barbara Radziszewska Thomas R. Cimato David M. Zlotnick Ronald Kohanski Gen Suzuki Malcolm McHenry View More
Kathleen Berkner

Staff
Molecular Cardiology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Cardiology
Biography

Gamma-glutamyl carboxylation of vitamin K-dependent proteins is essential for their activation, and a long-term goal of my laboratory is to understand the mechanism and regulation of carboxylation and how dysfunction leads to disease.

Research Intrest

vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR)

List of Publications
Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL.  Methylation of γ-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the γ-glutamyl carboxylase.  J Proteome Res. 2013 12(6):2365-74.
Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL. The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation. J Biol Chem. 2013 288(44):31556-66.
Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL.  Methylation of γ-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the γ-glutamyl carboxylase.  J Proteome Res. 2013 12(6):2365-74. 
Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL. The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation. J Biol Chem. 2013 288(44):31556-66.
Experts in United States of America
Jairaj K. Acharya John Belote Wayde Brown Aimée M. Dudley Jon P Mochel Rabaa M. Al-Rousan Chancellor, Renate Karen Lee Abt Lin Li Hui-Hsien Chou Hamed I. Aly Cory K. Adams Mark Ehrensberger Jose Buitrago Gerhard J. Barone Jacquelyne Adams Jon Calabria Shelley Cannady Susan B. Adams Stoica George Daniel E. Acuna Tal Amasay Jason R. Wiles Matthew H Andersen Brian Rothman View More