Katerina Gurova

Professor
Department of Cell Stress Biology
Roswell Park Cancer Institute
United States of America

Professor Oncology
Biography

Dr. Katerina Gurova came to Roswell Park Cancer Institute (RPCI) from Cleveland BioLabs, where she served as Director of Anti-Cancer Drug Discovery. Before joining Cleveland BioLabs, she worked as a Project Scientist in the Department of Molecular Genetics at The Cleveland Clinic.Dr. Gurova earned her medical degree from the Sechenov Medical Academy and a doctoral degree in experimental oncology from the Blokhin Cancer Research Center, both located in Moscow, Russia.Dr. Gurova’s research interests are focused on the discovery and development of new anticancer drugs. Specifically, she identified a new class of prospective anticancer agents named curaxins which are capable of simultaneous targeting of several signal transduction pathways that are frequently deregulated in cancer, including p53 and NF-kappaB. Her laboratory at RPCI is working on deciphering molecular mechanisms, optimizing therapeutic properties of curaxins and on the development of new approaches to treatment of hormone-refractory prostate cancer.

Research Intrest

discovery of new anti-cancer agents through different approaches, their testing and early stage development as well as understanding the mechanisms of their activity

List of Publications
Burkhart CA, Gudkov AV, Gurova KV, Komarov PG, Isachenko N, et al. (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer research 69: 6573-6580
Gurova K, Gudkov AV, (2010) Targeting transcriptional regulators for simultaneous modulation of p53 and NF-kappa B in cancer treatment. Proceedings of the American Association for Cancer Research Annual Meeting 51:1418
Gasparian AV, Neznanov N, Jha S, Galkin O, Gurova KV, et al. (2010) Inhibition of encephalomyocarditis virus and poliovirus replication by quinacrine: implications for the design and discovery of novel antiviral drugs. Journal of virology 84: 9390-9397