Jose Javier Bravo Cordero

Assistant Professor
Medicine, Hematology and Medical Oncology
Mount Sinai School of Medicine
United States of America

Professor Haematology
Biography

Dr. Bravo-Cordero was trained as a cell biologist and molecular biologist. He earned his bachelor’s degree at Autonoma University of Madrid (Spain) and his PhD in Cancer Biology at the Spanish National Cancer Institute (CNIO, Spain) working on mechanisms of tumor cell invasion in 3D collagen matrices by using high-resolution imaging. During his postdoctoral training, he extended his expertise in breast cancer metastasis by applying unique imaging technologies such as FRET microscopy and intravital imaging at the Albert Einstein College of Medicine in New York. He studied the spatiotemporal activation of RhoGTPases during invasion by using a series of imaging tools (FRET biosensors) to visualize GTPase activation in real time in living cells. Dr. Bravo-Cordero's expertise ranges from microscopy (FRET microscopy, in vivo imaging) to cell biology and mouse models. His laboratory is investigating the mechanisms of tumor cell dissemination and metastasis of breast cancer by applying high-resolution imaging techniques. In September 2015, he joined the Division of Hematology and Oncology, the Tisch Cancer Institute and the Microscopy CORE at Icahn School of Medicine at Mount Sinai as an assistant professor.

Research Intrest

Cancer, Cell Adhesion, Cell Biology, Cell Motility, Chemokines, Chemotaxis, Cytoskeleton, Extracellular Matrix, Image Analysis, Imaging, Macrophage, Metastasis, Migration, Molecular Biology, Two-Photon Imaging

List of Publications
Spiering D, Bravo-Cordero JJ, Moshfegh Y, Miskolci V, Hodgson L (2013) Quantitative ratiometric imaging of FRET-biosensors in living cells. Methods in cell biology.
Bravo-Cordero JJ, Hodgson L, Condeelis JS (2014) Spatial regulation of tumor cell protrusions by RhoC. Cell adhesion & migration.
Moshfegh Y, Bravo-Cordero JJ, Miskolci V, Condeelis J, Hodgson L (2014) A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nature cell biology.
Beaty BT, Wang Y, Bravo-Cordero JJ, Sharma VP, Miskolci V, etal (2014) Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. The Journal of cell biology.
Valenzuela-Iglesias A, Sharma VP, Beaty BT, Ding Z, Gutierrez-Millan LE, etal (2015) Profilin1 regulates invadopodium maturation in human breast cancer cells. European journal of cell biology.