José M. Bruno-Bárcena

Professor
Department of Plant & Microbial Biology
North Carolina State University
United States of America

Professor Plant Sciences
Biography

Courses taught: MB 180 Introduction to Applied Bioprocessing (summer II); MB 320 Fundamentals of Microbial Cell Culture; MB 420/520 Fundamentals of Microbial Cell Bio-transformations (fall); MB 455/555 Microbial Biotechnology (spring).

Research Intrest

There is a critical need for the systematic identification and testing of new gene modulated states that participate in the enhancement of cellular stress resistance. In our laboratory we use the new era of genomic tools that make it possible to identify point mutations, insertions, deletions and/or translocations that have occurred in offspring strains following defined selection processes. In the near future, this comparative approach will provide valuable insights for identifying gene combinations and biochemical pathways that play a role in microbial metabolism and this information may be applied to further improve production using strategic strain modifications. Our primary research interests are the study of Gram positive organisms and we investigate different, but complementary, areas of study with a focus on functional probiosis and bioenergy. Thus far our bioprocessing research has generated technology, peer-reviewed publications, and intellectual property to be directly implemented and translated into the generation of biofuels and functional foods. We have dedicated significant amounts of time towards implementing these new overlapping bioprocessing research areas that target prime university interests.

List of Publications
Sandoval-Espinola WJ, Chinn M, Bruno-Barcena JM (2015) Inoculum optimization of Clostridium beijerinckii for reproducible growth. FEMS Microbiol Lett. Oct;362(19). doi: 10.1093/femsle/fnv164.
Dagher SF, Bruno-Bárcena JM (2015) A novel N-terminus region of the membrane β-hexosyltransferase; its role in secretion of soluble protein by Pichia pastoris. Microbiology. 2015 Nov 9. doi: 10.1099/mic.0.000211.
Noar JD, Bruno-Bárcena JM (2016) Protons and pleomorphs: aerobic hydrogen production in Azotobacters. World J Microbiol Biotechnol. Feb;32(2):29. doi: 10.1007/s11274-015-1980-5