José Esté

Principal Investigator
HIV Pathogenesis
Spain

Biography

Dr. Esté’s laboratory focuses on the study of cofactors associated with HIV-1 and their links to AIDS pathogenesis with a view to how this information might allow the development of new therapeutic strategies. Dr. Esté has a doctorate in Medical Science from the Katholieke Universiteit Leuven. He participated in characterizing and developing the first class of CXCR4 HIV co-receptor antagonists and in characterizing co-receptor change induced by entry inhibitors. He has co-authored some 160 papers in international journals and has supervised 12 doctoral theses in the last ten years and filed four international patents in the last five years. His research group has received ongoing external funding since 1999, from national and European projects and from contracts with pharmaceutical companies. He is the current president of the International Society for Antiviral Research (2016-2018) and participates in the organization of various international conferences. He is editor of Antiviral Research, reviewing editor of the Journal of Biological Chemistry and a member of the editorial board of Antimicrobial Agents and Chemotherapy. Appointed as an expert to the Research Executive Agency (REA) of the European Commission, he participates in several panels that evaluate international projects.

Research Intrest

Virology, Imfecticious disease, Biochemistry, Microbial molecular biology, Immunology

List of Publications
Moll, M., Andersson, S. K., Smed-Sörensen, A., & Sandberg, J. K. (2010). Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood, 116(11), 1876–1884.
Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura, Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors, ChemMedChem, 2016, 11, 8, 940
Badia R, Angulo G, Riveira-Muñoz E, et al. Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1. Journal of Antimicrobial Chemotherapy. 2016;71(2):387-394.
Fedora Grande, Gilda Giancotti, Giuseppina Ioele, Maria A. Occhiuzzi and Antonio Garofalo European Journal of Medicinal Chemistry, 2017 j.ejmech.2017.08.027
Eduardo Pauls, Esther Jimenez, Alba Ruiz, Marc Permanyer, Ester Ballana, Helena Costa, Rute Nascimiento, R. Michael Parkhouse, Ruth Peña, Eva Riveiro-Muñoz, Miguel A. Martinez, Bonaventura Clotet, José A. Esté, Margarida Bofill The Journal of Immunology May 1, 2013, 190 (9) 4736-4741;