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John P Kirwan

Staff
Pathobiology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Pathology
Biography

My lab is focused on discovering physiological and cellular mechanisms that cause insulin resistance, diabetes, and obesity. In partnership with the Nestle Research Center in Lausanne, Switzerland, we are currently examining the effects of a whole grain versus refined grain diet on lean body mass, energy balance, and protein turnoveron body composition and energetics in overweight and obese adults.

Research Intrest

Diabetes; obesity; nutrition; exercise; fatty liver disease; muscle; insulin resistance; translational science; physiology; cell biology; molecular biology

List of Publications
Zein, C.O., R. Lopez, J.P. Kirwan, L.M. Yerian, S.L. Hazen, A.E. Feldstein, A.J. McCullough. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism. Hepatology. 56:1291-9, 2012.
Zein, C.O., R. Lopez, J.P. Kirwan, L.M. Yerian, S.L. Hazen, A.E. Feldstein, A.J. McCullough. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism. Hepatology. 56:1291-9, 2012
Schauer, P.R., S.R. Kashyap, K. Wolski, S.A. Brethauer, J.P. Kirwan, C.E. Pothier, S. Thomas, B. Abood, S.E. Nissen, D.L. Bhatt. Bariatric surgery versus intensive medical therapy in obese diabetic patients. N. Engl. J. Med., 366:1567-76, 2012.
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