John Cijiang He

Professor
Medicine, Nephrology and Pharmacological Sciences
Icahn School of Medicine at Mount Sinai
United States of America

Professor Nephrology
Biography

Dr. John Cijiang He is a former graduate from Shanghai Second medical University. He got his PhD in Physiology at University of Paris VII, France. Then, he got his further research training as a visiting scientist at NIH in Maryland and The Picower Institute for Medical Research in New York. He completed his medical residency at SUNY down state and clinical nephrology fellowship at Mount Sinai Hospital in New York. Currently, he is a tenured full Professor of Medicine and Pharmacology/Systems Therapeutics at Icahn School of Medicine at Mount Sinai. He holds the title of Irene and Dr. Arthur Fishberg endowed chair of Nephrology. He is the division chief of Nephrology at both Mount Sinai Hospital and James J Peters Veteran Affair medical Center. He was the past President of the New York Society of Nephrology. Currently, he is the President of Chinese American Society of Nephrology. He is also a visiting professor at both Nanjing University and Shanghai Jiaotong University. He has been funded by multiple NIH and VA grants and has published more than 100 papers in the peer-reviewed scientific journals. His major research areas include podocyte biology and pathology, signaling networks in kidney cells, systems biology of kidney disease, and kidney fibrosis. His major clinical interest includes diabetic kidney disease, viral-induced kidney disease, and primary glomerular disease. Certifications Nephrology American Board of Internal Medicine Clinical Focus Glomerulonephritis Kidney Failure Multi-Disciplinary Training Area Biophysics and Systems Pharmacology [BSP] Education MD, Shanghai 2nd Medical School MD, Shanghai Second Medical College MS, University of Paris VII Rui-Jin Hospital, Shanghai 2nd Medical School Tenon Hospital PhD, University of Paris VII Tenon Hospital SUNY Health Science Center SUNY Health Science Center The Mount Sinai Medical Center Residency, Internal Medicine, S.U.N.Y., Health Science Center Fellowship, Metabolic Diseases, National Institutes of Health Fellowship, Renal Medicine, Mount Sinai Hospital

Research Intrest

AIDS/HIV, Diabetes, Kidney, Retinoic Acid, Signal Transduction

List of Publications
Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, etal (2012) A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nature medicine Vol: 18.
Ratnam KK, Feng X, Chuang PY, Verma V, Lu TC, Wang J, Jin Y, etal (2011) Role of the retinoic acid receptor-α in HIV-associated nephropathy. Kidney international Vol: 79.
Ratnam KK, Feng X, Chuang PY, Verma V, Lu TC, etal (2011)Role of the retinoic acid receptor-α in HIV-associated nephropathy. Kidney international Vol: 79.
Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, etal (2009) Reduction of Stat3 activity attenuates HIV-induced kidney injury. Journal of the American Society of Nephrology : JASN Vol: 20.
Lu TC, Wang Z, Feng X, Chuang P, Fang W, etal (2008) Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Molecular and cellular biology Vol: 28.
Chuang PY, Yu Q, Fang W, Uribarri J, He JC (2007) Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor. Kidney international Vol: 72.
Cai W, He JC, Zhu L, Lu C, Vlassara H (2006) Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Proceedings of the National Academy of Sciences of the United States of America Vol: 103.
He C, Esposito C, Phillips C, Zalups RK, Henderson DA, Striker GE, etal (1996) Dissociation of glomerular hypertrophy, cell proliferation, and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. The Journal of clinical investigation Vol: 97.