Johannes Berger

Professor
Center for Brain Research (Division of Pathobiology of the N
Medical University of Vienna
Austria

Professor Pathology
Biography

Dr. Johannes Berger is currently working as a Professor in the Department of Center for Brain Research (Division of Pathobiology of the Nervous System), Medical University of Vienna ,  Austria. His research interests includes Brain Research. He /she is serving as an editorial member and reviewer of several international reputed journals. Dr. Johannes Berger is the member of many international affiliations. He/ She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to Brain Research.

Research Intrest

My main research focus is to understand the importance of different peroxisomal metabolic pathways for the proper function of the brain. The research is designed to elucidate molecular mechanisms underlying the different phenotypes of X-linked adrenoleukodystrophy and to develop novel therapeutic approaches. The ether phospholipid biosynthesis is disturbed in a group of inherited peroxisomal disorders but increasing evidence emerges suggesting a role of ether phospholipids in the pathogenesis of late onset neurodegenerative diseases such as Alzheimer’s disease. Thus, the characterization of molecular consequence of ether phospholipid deficiency for the nervous system is another focus of our laboratory.

List of Publications
Wiesinger C, Kunze M, Regelsberger G, Forss-Petter S, Berger J. (2013). Impaired Very Long-Chain Acyl-CoA β-Oxidation in Human X-ALD Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction. J Biol Chem, 288: 19269-19279
Weber F, Wiesinger Ch, Forss-Petter S, Regelsberger G, Einwich A, Weber W, Kohler W, Stockinger H, Berger J, (2014). X-linked adrenoleukodystrophy: Very long-chain fatty acid metabolism is severely impaired in monocytes but not in lymphocytes. Hum Mol Genet, 23 (10): 2542-2550 | Article (PDF
Kunze M, Malkani N, Maurer-Stroh S, Wiesinger C, Schmid J, Berger J (2015). Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: The Co-receptor PEX5L drastically increases the Interaction Strength between the Cargo Protein and the Receptor. PEX7 J Biol Chem, 290: 4928-4940