Jan S. Potempa

Professor
Oral Immunology & Infectious Diseases
University of Louisville
United States of America

Professor Immunology
Biography

 Dr. Potempa earned his Ph.D. and D.Sc. (habilitation) in Biochemistry in 1982 and 1993, respectively, from Jagiellonian University, Krakow, Poland.  In 1985-1988 he conducted postdoctoral research at the University of Georgia and from 1989 to 2008, he worked there as a Senior Research Scientist. From January 2009, Dr. Potempa was recruited to the University of Louisville Dental School as a Professor and Academic Scholar.  Simultaneously, Dr. Potempa maintained his teaching and research position at the Jagiellonian University since 1983, where he was head of Department of Microbiology since 2001 and promoted to Research Professor in 2005. 

Research Intrest

 Bacterial pathogens interaction with the innate immunity system, proteolytic enzymes of bacterial pathogens

List of Publications
Guzik K, Potempa J. Friendly fire against neutrophils: proteolytic enzymes confuse the recognition of apoptotic cells by macrophages. Biochimie. 2008 Feb 29;90(2):405-15.
Dubin G, Wladyka B, Stec-Niemczyk J, Chmiel D, Zdzalik M, Dubin A, Potempa J. The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity. Biological chemistry. 2007 Feb 1;388(2):227-35.
Sheets SM, Potempa J, Travis J, Fletcher HM, Casiano CA. Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis. Infection and immunity. 2006 Oct 1;74(10):5667-78.
Mydel P, Takahashi Y, Yumoto H, Sztukowska M, Kubica M, Gibson III FC, Kurtz Jr DM, Travis J, Collins LV, Nguyen KA, Genco CA. Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS pathogens. 2006 Jul 28;2(7):e76.