James H. Finke

Staff
Immunology Medicine
Cleveland Clinic Lerner Research Institute
United States of America

Professor Immunology
Biography

My research effort is directed toward defining the mechanisms by which the tumor microenvironment can negatively influence the development of T cell immunity to cancer.

Research Intrest

Tumor immunity, T lymphocyte effectors, immunotherapy, T-cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

List of Publications
Vijayaraghavalu S (2013) Highly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest. Mol Pharmaceutics
Ko JS, Rayman P, Ireland J, Swaidani S, Rini B, (2010) Directed and Differential Suppression of Myeloid-Derived Suppressor Cell Subset by Sunitinib is Compartmentally Constrained. Cancer Research 70(9): 3526-3536.
Raychaudhuri B, Rayman P, Ireland J, Ko J, Rini BI, et al. (2011) Myeloid derived suppressor cell accumulation and function in newly diagnosed glioblastoma patients. Neuro-Oncology.