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Irina V Budunova

Associate Professor
Department of Dermatology
Northwestern University
United States of America

Professor Dermatology
Biography

Our research is focused on the role of the glucocorticoid receptor (GR) and its target genes in skin and prostate tumor development, and regulation of stem cells. We are also very much interested in translational aspects of the GR biology, and my laboratory has been involved in the development of novel selective GR activators (SEGRA) that preserve therapeutic potential of glucocorticoids but have fewer side effects. We also study the molecular mechanisms of the major side effect of topical glucocorticoids - skin atrophy using mice with knockout of identified GR target genes.

Research Intrest

skin and prostate tumor development, and regulation of stem cells

List of Publications
Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martinez J, Larcher F, Slaga TJ, Gutkind JS, Jorcano JL. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene. 2002 Jan 3;21(1):53.
Gasparian AV, Yao YJ, Kowalczyk D, Lyakh LA, Karseladze A, Slaga TJ, Budunova IV. The role of IKK in constitutive activation of NF-κB transcription factor in prostate carcinoma cells. Journal of cell science. 2002 Jan 1;115(1):141-51.
Experts in United States of America
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