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Experts in Bioinformatics and Systems Biology
Takeshi Kikuchi Neeraj Wadhwa Hui-Hsien Chou Lynn Adler Paltu Kumar Dhal Stein Aerts Kamal Rawal Abhishek Mitra NGAI Sai Ming Robert Sablowski Murodzhon Akhmedov Luciano Cascione Ivo Kwee MARISSA AMBIO Alberto Arribas Carmena Dr. Rajeev K. Tyagi TRUNG DAC NGUYEN Elizabeth A. Connor Gouher Ahmed Ramana Gosukonda View MoreMy research interests focus on bacterial pathogenesis, emphasizing bacterial biofilms, antimicrobial therapies and vaccine antigens. One major area of my research lab is otitis media (OM) or middle ear disease. Approximately 80 percent of children experience one episode of OM while others have recurrent infections. Chronic OM infection causes hearing impairment leading to developmental problems as these children reach school age. My laboratory has concentrated on two major causes of OM, Moraxella catarrhalis and Streptococcus pneumoniae. Our recent work suggests that M. catarrhalis colonization predisposes patients to colonization with S. pneumoniae in polymicrobial biofilms. The goals of this work are to define biofilm-associated factors and to identify signals that induce bacteria to transition from asymptomatic colonizers to pathogenic organisms leading to OM.
Biomedical science