Graham Lieschke

Professor
Medicine
Peter MacCallum Cancer Centre
Australia

Professor Haematology
Biography

Prof Lieschke received his medical science and medical degrees from the University of Melbourne in 1983. He undertook his specialist clinical training in medical oncology at the Royal Melbourne Hospital (RMH), obtaining his FRACP in 1991. His undergraduate laboratory and clinical research cultivated his interest in haematology, and as the first Ludwig Institute/RMH Clinical Fellow, he was part of the team that introduced the white blood cell growth factors into clinical practice. In his PhD project at the Ludwig Institute for Cancer Research (Melbourne Branch), he undertook one of Australia’s first gene knockout projects, proving that G-CSF was a key physiological regulator of granulocyte production. His postdoctoral training was at the Whitehead Institute in Cambridge, Massachusetts, USA, in tumour immunology. He returned to Australia in 1997 as an independent investigator. He established his zebrafish-based research program while at the Ludwig Institute for Cancer Research, and continued this as a Laboratory Head in the Cancer and Haematology Division of the Walter and Eliza Hall Institute. His research seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases. He has published over 100 scientific papers and co-edited 2 books. Prof. Lieschke is also passionate about the organ and choral music of J.S. Bach, an interest for which he was awarded the 2004 Dame Roma Mitchell Churchill Fellowship.

Research Intrest

His research seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases.

List of Publications
A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia. Pazhakh V, Clark S, Keightley MC, Lieschke GJ. Scientific reports. 2017; 7:44455.
The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ. Nature communications. 2017; 8:14911.
Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Witzel M, Petersheim D, Fan Y, Bahrami E, Racek T, Rohlfs M, Puchałka J, Mertes C, Gagneur J, Ziegenhain C, Enard W, Stray-Pedersen A, Arkwright PD, Abboud MR, Pazhakh V, Lieschke GJ, Krawitz PM, Dahlhoff M, Schneider MR, Wolf E, Horny HP, Schmidt H, Schäffer AA, Klein C. Nature genetics. 2017; 49(5):742-752.