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George R. Stark

Staff
Cancer Biology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Medicine
Biography

George has use a lentiviral vector to insert a strong promoter near genes in human cells, generating specific cell clones that over-express specific proteins, changing their properties in ways that we can select.

Research Intrest

Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock

List of Publications
Cheon H, Stark GR (2009) Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes.Proc Natl Acad Sci USA. 2009 Jun 9;106(23):9373-9378.
Yang J, Huang J, Dasgupta M, Sears N, Miyagi M (2010) Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci USA. 14;107(50):21499-504.
Tan MH, De S, Bebek G, Orloff MS, Wesolowski R (2012) Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.Breast Cancer Res Treat. ;131(3):849-858.
Experts in United States of America
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