George McDonald Church

Professor
Departmaent of Genetics
Harvard Medical School
United States of America

Professor Genetics
Biography

In the fall of 1973, Church began research work at Duke University with assistant professor of biochemistry, Sung-Hou Kim, work that continued a year later with Church in a graduate biochemistry program at Duke on an NSF fellowship.[7][10] As Peter Miller reported for the National Geographic series, "The Innovators". "As a graduate student at Duke… he used x-ray crystallography to study the three-dimensional structure of "transfer" RNA, which decodes DNA and carries instructions to other parts of the cell. It was groundbreaking research, but Church spent so much time in the lab—up to a hundred hours a week—that he neglected his other classes [in the fall of 1975]".

Research Intrest

Geonomics Synthetic Biology Genome engineering Bacteriology Biotechnology

List of Publications
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. George McDonald Church, Ph.D. Nature microbiology, February 6, 2017 Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity. George McDonald Church, Ph.D. ACS synthetic biology, February 10, 2017 Chari R, Yeo NC, Chavez A, Church GM
Addressing the ethical issues raised by synthetic human entities with embryo-like features. George McDonald Church, Ph.D. eLife, March 21, 2017 Aach J, Lunshof J, Iyer E, Church GM
Cogenerating Synthetic Parts toward a Self-Replicating System. George McDonald Church, Ph.D. ACS synthetic biology, March 29, 2017 Li J, Haas W, Jackson K, Kuru E, Jewett MC, Fan ZH, Gygi S, Church GM
Dissecting limiting factors of the Protein synthesis Using Recombinant Elements (PURE) system. George McDonald Church, Ph.D. Translation (Austin, Tex.), May 9, 2017 Li J, Zhang C, Huang P, Kuru E, Forster-Benson ETC, Li T, Church GM
Millstone: software for multiplex microbial genome analysis and engineering. George McDonald Church, Ph.D. Genome biology, May 25, 2017 Goodman DB, Kuznetsov G, Lajoie MJ, Ahern BW, Napolitano MG, Chen KY, Chen C, Church GM
Optimizing complex phenotypes through model-guided multiplex genome engineering. George McDonald Church, Ph.D. Genome biology, May 25, 2017 Kuznetsov G, Goodman DB, Filsinger GT, Landon M, Rohland N, Aach J, Lajoie MJ, Church GM
CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. George McDonald Church, Ph.D. Nature, July 12, 2017 Shipman SL, Nivala J, Macklis JD, Church GM