George F. Muschler

Staff
Biomedical Engineering
Cleveland Clinic Lerner Research Institute
United States of America

Professor Medicine
Biography

Our laboratory is focused on advancing the field of tissue engineering through development of new strategies for preservation, repair, regeneration, augmentation, or replacement of musculoskeletal tissues. We focus in three key areas: the harvest, processing and transplantation of adult connective tissue stem cells and progenitors (CTPs) for treatment of fractures and problems of degenerative joints; the effects of aging and osteoporosis on CTPs; and optimizing assays for CTPs and other stem cells.

Research Intrest

George is Stem cell; progenitor cell; bone; cartilage; arthritis; aging; osteoporosis; bone loss; fracture non-union; blood; bone marrow; regenerative medicine; tissue engineering; gender differences; cell therapy; cell processing; orthopaedics; orthopaedic surgery; rheumatology;

List of Publications
Caralla T, Joshi P, Fleury S, Luangphakdy V, Shinohara K, Pan H, (2013) In vivo transplantation of autogenous marrow-derived cells following rapid intraoperative magnetic separation based on hyaluronan to augment bone regeneration. Tissue Eng Part A. 2013 Jan;19(1-2):125-134.
Caralla T, Boehm C, Hascall V, Muschler G (2012) Hyaluronan as a novel marker for rapid selection of connective tissue progenitors. Ann Biomed Eng. Dec;40(12):2559-2567.
Tomek IM, Sabel AL, Froimson MI, Muschler G, Jevsevar DS, et al. (2012) A collaborative of leading health systems finds wide variations in total knee replacement delivery and takes steps to improve value. Health Aff (Millwood).