Fiona Tomley

Professor of Experimental Parasitology
Pathobiology and Population Sciences
Royal Veterinary College University of London
United Kingdom

Professor Toxicology
Biography

Fiona graduated in Bacteriology and Virology at Manchester University (1977) where she also completed her PhD on vaccinia virus DNA polymerase. After four years as a post-doc in virology at Cambridge Vet School and Department of Pathology, Fiona joined the Houghton Poultry Research Station (later the Institute for Animal Health) in 1984 to develop fowlpoxvirus as a replicating vaccine vector for important viral diseases of chickens including infectious bronchitis and Newcastle Disease. Since the late 1980's Fiona has worked on protozoan parasites (Eimeria species) of poultry with a focus on understanding how these parasites recognise and invade target host cells. Alongside basic research, she has applied genomic, proteomic and transgenic approaches to Eimeria species and continues to have a strong interest in the development of new types of vaccines for poultry infectious diseases, working in collaboration with industry. During her time at the IAH,  Fiona held senior managment posts including Head of the Division of Microbiology (2005-2010) and Deputy Director of Science (2008-2010).  She joined the RVC at the end of 2010 as Professor of Experimental Parasitology and became head of Pathology and Pathogen Biology in 2014.

Research Intrest

Protozoan parasites of the genus Eimeria cause coccidiosis, a severe enteritis that affects many livestock species and is most serious in poultry. The parasites are transmitted by the faecal-oral route and they rapidly invade epithelial cells of the gut, causing severe damage and leading to the build-up of heavy parasite loads in the environment. In the absence of measures to control Eimeria parasites, outbreaks of severe clinical coccidiosis with high morbidity and mortality are inevitable.

List of Publications
Blake DP, Tomley FM (2014) Securing poultry production from the ever-present Eimeria challenge. Trends Parasitol. 2014 Jan;30(1):12-9
Rao ASRS, Tomley F, Blake D (2015).Understanding Chicken Walks on n x n Grid: Hamiltonian Paths, Discrete Dynamics and Rectifiable Paths. Mathematical Methods in the Applied Sciences (Wiley-Blackwell) DOI: 10.1002/mma.3301
Pritchard J, Kuster T, Sparagano O, Tomley F(2015). Understanding the biology and control of the poultry red mite Dermanyssus gallinae: a review. Avian Pathol. 2015;44(3):143-53. doi: 10.1080/03079457.2015.1030589.
Nolan MJ, Tomley FM, Kaiser P, Blake DP (2015). Quantitative real-time PCR (qPCR) for Eimeria tenella replication--Implications for experimental refinement and animal welfare.Parasitol Int. 2015 Oct;64(5):464-70. doi: 10.1016/j.parint.2015.06.010.
Blake DP, Clark EL, Macdonald SE, Thenmozhi V, Kundu K, Garg R, Jatau ID, Ayoade S, Kawahara F, Moftah A, Reid AJ, Adebambo AO, Álvarez Zapata R, Srinivasa Rao AS, Thangaraj K, Banerjee PS, Dhinakar-Raj G, Raman M, Tomley FM (2015). Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development.Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5343-50. doi: 10.1073/pnas.1506468112.
Wu Z, Hu T, Rothwell L, Vervelde L, Kaiser P, Boulton K, Nolan MJ, Tomley FM, Blake DP, Hume DA. (2016) Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA Dev Comp Immunol. 2016 Oct;63:206-12. doi: 10.1016/j.dci.2016.04.016.
Clark EL, Macdonald SE, Thenmozhi V, Kundu K, Garg R, Kumar S, Ayoade S, Fornace KM, Jatau ID, Moftah A, Nolan MJ, Sudhakar NR, Adebambo AO, Lawal IA, Álvarez Zapata R, Awuni JA, Chapman HD, Karimuribo E, Mugasa CM, Namangala B, Rushton J, Suo X, Thangaraj K, Srinivasa Rao AS, Tewari AK, Banerjee PS, Dhinakar Raj G, Raman M, Tomley FM, Blake DP. Cryptic Eimeria genotypes are common across the sourthern but not northern hemisphere. Int J Parasitol. 2016 Aug;46(9):537-44. doi: 10.1016/j.ijpara.2016.05.006.
Pritchard J, Küster T, George D, Sparagano O, Tomley F.(2016) Impeding movement of the poultry red mite Dermanyssus gallinae Vet Parasitol. 2016 Jul 30;225:104-7. doi: 10.1016/j.vetpar.2016.06.006. Epub 2016 Jun 6.
Marugan-Hernandez V, Cockle C, Macdonald S, Pegg E, Crouch C, Blake DP, Tomley FM (2016) Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system. Parasit Vectors. 2016 Aug 23;9:463. doi: 10.1186/s13071-016-1756-2.
Clark EL, Tomley FM, Blake DP (2016) Are Eimeria genetically diverse and does it matter? Trends Parasitol. 2016 Sep 1. pii: S1471-4922(16)30124-6. doi: 10.1016/j.pt.2016.08.007