Erik Nelson

Assistant Professor
Division of Nutritional Sciences
University of Illinois at urbana champaign
United States of America

Professor Nutrition
Biography

He has don his 2002 B.Sc. in Zoology, University of Calgary, Canada, 2008 Ph.D. in Comparative Endocrinology, University of Calgary, Canada 2008-2014 Postdoctoral Associate, Duke University School of Medicine, Durham, NC.

Research Intrest

The research of Dr. Nelson is focused on the elucidating the endocrine and metabolic control of cancer pathophysiology. He is specifically interested in the molecular physiology behind how obesity and hypercholesterolemia contribute to cancer progression. His work has found that a metabolite of cholesterol 27-hydroxycholesterol, can bind to and activate the estrogen receptors, promoting breast tumor growth. 27-hydroxycholesterol was also found to increase breast cancer metastasis, a striking finding considering that the majority of breast cancer patients will eventually succumb to metastatic disease, not to the primary tumor. His laboratory is currently working on determining the mechanisms behind this observation and how other endocrine factors influence metastasis. The major goal is to develop novel lifestyle or therapeutic strategies to prevent and treat metastatic disease. This research is of incredible importance, given the current obesity crisis and that the majority of breast cancer patients will eventually relapse with metastatic disease.

List of Publications
McDonnell D.P., Park S., Goulet M.T., Jasper J.S., Wardell S.E., Chang CY, Norris J.D., Guyton J.R. and Nelson E.R. (2014). Obesity, Cholesterol Metabolism and Breast Cancer Pathogenesis. Cancer Research. 74(18): 4976-82. PMCID: PMC4167494.
Safi R., Nelson E.R., Chitneni S.K., Franz K.J., George D.J., Zalutsky M.R., and McDonnell D.P. (2014). The Copper-Signaling Axis as a Target for Prostate Cancer Therapeutics. Cancer Research. 15;74(20):5819-31. PMCID: PMC4203427.
Nelson E.R., Chang, C.Y., and McDonnell, D.P. (2014). Cholesterol and Breast Cancer Pathophysiology. Trends in Endocrinology and Metabolism. 25(12):649-655. PMCID: PMC4268141.