Dr V Stalin Raj

Associate Professor
virology
Indian Institute of Science Education and Research Thiruvananthapuram
India

Professor Pathology
Biography

BSc –1999,Microbiology, University of Madras, Chennai, Tamil Nadu, India. MSc –2001, Biotechnology, Madurai Kamaraj University, Madurai, Tamil Nadu, India. PhD –2007, Biotechnology, Pathology and Microbiology in Aquaculture, University of Madras, Chennai, India. Central Institute of Brackish water aqua culture (CIBA), ICAIR, Chennai, India. Thesis Title: Morphological and Molecular Studies on White Spot Syndrome Virus (WSSV) and Monodon Baculovirus (MBV) Affecting Farmed Penaeus monodon from the South East Coast of India. Supervisor: Dr. KK. Vijayan, Director, Central Institute of Brackish water aqua culture (CIBA), ICAIR, Chennai, India Work Experience Associate Professor : School of Biology, IISER Thiruvananthapuram Jul 2017 to till date Scientist : Erasmus Medical Center, Rotterdam, Netherlands. oct 2010 to Jun 2017. Post-doctoral Fellow : University of Liege, Belgium. Oct 2009 to Sep 2010. Senior Research Fellow : Central Institute of Brackish water Aquaculture Chennai, India. Sep 2001 to April 2005.

Research Intrest

My research interests include both basic and applied research on the topic of emerging and re-emerging viral diseases in humans, livestock, and wildlife. Emerging and re-emerging infectious diseases are a major public health concern and cause considerable socioeconomic problems worldwide. Over 30 new infectious pathogens have been detected worldwide in the last three decades and most of these emerging and re-emerging pathogens are viruses. Mostly unpredictable, emerging and re-emerging infection outbreaks occur at an unprecedented and unrelenting pace, due to social and environmental factors and microbial evolution, such as population growth, urbanization, deforestation, livestock production, climate change, and pathogen mutation. Because of their high mutational rate and adaptability to changing environments, including host switch, RNA viruses are among the most frequent causes of such emerging diseases.

List of Publications
1.V. Stalin Raj, Hundie GB, Schürch AC, Smits SL, Pas SD, Le Pogam S, Janssen HLA, de Knegt RJ, Osterhaus ADME, Najera I, Boucher CA, Haagmans BL. Identification of HCV Resistant Variants against Direct Acting Antivirals in Plasma and Liver of Treatment Naïve Patients. Scientific Report. 2017 Jul 5;7(1):4688. doi: 10.1038/s41598-017-04931-y. 2.Hundie GB, V. Stalin Raj, GebreMichael D, Pas SD, Haagmans BL. Genetic diversity of hepatitis C virus in Ethiopia. PLoS One. 2017 Jun 1;12(6):e0179064. doi: 10.1371/journal.pone.0179064. 3.Vergara-Alert J, V. Stalin Raj, Muñoz M, Abad FX, Cordón I, Haagmans BL, Bensaid A, Segalés J. Middle East respiratory syndrome coronavirus experimental transmission using a pig model. Transbound Emerg Dis. 2017 Jun 26. doi: 10.1111/tbed.12668. 4.Hundie GB, V. Stalin Raj, Gebre Michael D, Haagmans BL. Seroepidemiology of hepatitis B and C virus infections among blood donors in Ethiopia. J Med Virol. 2017 Jan 25. doi: 10.1002/jmv.24770. [Epub ahead of print]. (Q3) 5.Hundie GB, V. Stalin Raj, Gebre Michael D, Pas SD, Osterhaus AD, Koopmans MP, Smits SL, Haagmans BL. 2015. A novel hepatitis B virus subgenotype D10 circulating in Ethiopia. Journal of Viral Hepatitis. 2017. Feb;24(2):163-173. doi: 10.1111/jvh.12631.(Q1). 6.Júlia Vergara-Alert1, Judith M.A. van den Brand, W. Widagdo, Marta Muñoz, V. Stalin Raj, Debby Schipper, David Solanes, Ivan Cordón, Albert Bensaid, Bart L. Haagmans, Joaquim Segalés. 2016. Susceptibility of different livestock animal species for Middle East respiratory syndrome coronavirus infection. Emerging Infectious Diseases. 2017 Feb;23(2):232-240. doi: 10.3201/eid2302.161239. (Q1, top10%). 7.Annemiek A. van der Eijk, Perry J. van Genderen, Rob M. Verdijk, Chantal B. Reusken, Ramona Mögling, Jeroen J.A. van Kampen, W. Widagdo, Georgina I. Aron, Corine H. GeurtsvanKessel, Suzan D. Pas, V. Stalin Raj, Bart L. Haagmans, Marion P.G. Koopmans. 2016. Miscarriage Associated with Zika Virus Infection. New England Journal of Medicine. 375:1002-1004. . doi: 10.1056/NEJMc1605898. (Q1, top10%). 8.Mart M. Lamers, Saskia L. Smits, Gadissa B. Hundie, Marion Koopmans, Albert D.M.E. Osterhaus, Bart L. Haagmans*, V. Stalin Raj*. 2016. Naturally Occurring Recombination in Ferret Coronaviruses Revealed by Complete Genome Characterization. Journal of General Virology. 97: 2180-2186. doi: 10.1099/jgv.0.000520. (Q2). 9.Reusken CBEM, Schilp C, V. Stalin Raj, De Bruin E, Kohl RHG, Farag EABA, et al. 2016. MERS-CoV infection of alpaca in a region where MERS-CoV is endemic. Emerging Infectious Diseases. 22: 1129-1131. doi: 10.3201/eid2206.152113. (Q1, top 10%). 10.Widagdo W, V. Stalin Raj, Schipper D, Kolijn K, van Leenders GJ, Bosch BJ, Bensaid A, Segalés J, Baumgärtner W, Osterhaus AD, Koopmans MP, van den Brand JM, Haagmans BL. 2016. Differential expression of the MERS-coronavirus receptor in the upper respiratory tract of humans and dromedary camels. Journal of Virology. 90:4838-42. (IF 4.44) doi: 10.1128/JVI.02994-15. (Q1) 11.Mart M. Lamers*, V. Stalin Raj*, Mah’d Shafei* , Sami Sheikh Ali, Sultan M. bdallh, · Mahmoud Gazo, · Samer Nofal, · Xiaoyan Lu, Dean D. Erdman, Marion P. Koopmans, Mohammad Abdallat, Aktham Haddadin, Bart L. Haagmans. 2016. Deletion Variants of Middle East Respiratory Syndrome Coronavirus from Humans, Jordan, 2015. Emerging Infectious Diseases. 22:716-719. doi: 10.3201/eid2204.152065. (Q1, top 10%). 12.Haagmans BL, van den Brand JM, V. Stalin Raj, Volz A, Wohlsein P, Smits SL, Schipper D, Bestebroer TM, Okba N, Fux R, Bensaid A, Solanes Foz D, Kuiken T, Baumgärtner W, Segalés J, Sutter G, Osterhaus AD. 2016. An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science. 351(6268): 77-81. doi: 10.1126/science.aad1283. (Q1, top 10%). 13.Hundie GB, V. Stalin Raj, Gebre Michael D, Pas SD, Osterhaus AD, Koopmans MP, Smits SL, Haagmans BL. 2015. Molecular epidemiology and genetic diversity of hepatitis B virus in Ethiopia. Journal of Medical Virolology. 88: 1035. (IF2.37) doi: 10.1002/jmv.24437. (Q3) 14.Haagmans, B. L., J. M. A. van den Brand, L. B. Provacia, V. Stalin Raj, K. J. Stittelaar, S. Getu, L. de Waal, T. M. Bestebroer, G. van Amerongen, G. M. G. M. Verjans, R. A. M. Fouchier, S. L. Smits, T. Kuiken, and A. D. M. E. Osterhaus. 2015. Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits. Journal of Virology 89:6131-6135. (IF 4.44) doi: 10.1128/JVI.00661-15. (Q1) 15.Farag EA, Reusken CB, Haagmans BL, Mohran KA, V. Stalin Raj, Pas SD, Voermans J, Smits SL, Godeke GJ, Al-Hajri MM, Alhajri FH, Al-Romaihi HE, Ghobashy H,El-Maghraby MM, El-Sayed AM, Al Thani MH, Al-Marri S, Koopmans MP. 2015. Highproportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014. Infection Ecology Epidemiology. 5:28305. (IF 1.5) doi: 10.3402/iee.v5.28305 (NA).