Dr Tapas K. Manna

Associate Professor
Biochemistry
Indian Institute of Science Education and Research Thiruvananthapuram
India

Professor Biochemistry
Biography

Ph. D. in Biochemistry (2004), Jadavpur University (Bose Institute, Kolkata) M.Sc. in Chemistry (1997) Calcutta University EXPERIENCE Post-doctoral Fellow: Univ. of Massachusetts Medical School, Worcester Postdoc-doctoral Fellow: Univ. of California, Santa Barbara

Research Intrest

Microtubule cytoskeleton, mitosis, centrosome and spindle pole regulation, drug development, ciliogenesis RESEARCH:

List of Publications
Thomas GE, Bandopadhyay K, Sutradhar S, MR Renjith, Singh P, KK Gireesh, Simon S, Badarudeen Binshad, Gupta H, Banerjee M, Paul R, Mitra J, Manna TK* (2016) EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice. Nature Communications, doi:10.1038/NCOMMS11665, May 26. Gupta H, Badarudeen Binshad, George A, Thomas GE, Manna TK.* (2015) Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in vitro by Binding to Microtubules. Biochemistry 54: 6413-22. Suhail TV, Singh P, Manna TK.* (2015) Suppression of centrosome protein TACC3 induces G1 arrest and cell death through activation of p38-p53-p21 stress signaling pathway. European Journal of Cell Biology, 94: 90-100 Thomas GE, Sreeja JS, KK Gireesh, Gupta H, Manna TK.* (2015) Suppression of +TIP protein EB1 sensitizes cells to paclitaxel-induced proliferation inhibition and apoptosis through inhibition of paclitaxel binding on microtubules. International Journal of Oncology, 46, 133-146 Singh P, Thomas GE, KK Gireesh, Manna TK.* (2014) TACC3 regulates microtubule nucleation by affecting gamma-tubulin ring complexes. Journal of Biological Chemistry, 289, 31719-31735 KK Gireesh, Sreeja JS, Chakraborti S, Singh P, Thomas GE, Gupta H, Manna TK.* (2014) Microtubule +TIP protein EB1 binds to GTP and undergoes dissociation from dimer to monomers on binding GTP. Biochemistry, 53, 5551-5557 KK Gireesh, Rashid A, Chakraborty S, Panda D, Manna TK*. (2012) CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells. Biochemical Pharmacology, 84, 633-645. Manna T, Thrower DA, Honnappa S, Steinmetz MO, Wilson L. (2009) Regulation of microtubule dynamic instability in vitro by differentially phosphorylated stathmin. Journal of Biological Chemistry, 284, 15640-15649. Sivaram M, Wadzinski, T, Redick S, Manna T, Doxsey, SJ (2009) Dynein light intermediate chain 1 is required for progress spindle assembly checkpoint. EMBO Journal, 28, 902-914. Manna T, Honnappa S, Steinmetz MO, Wilson L. (2008) Suppression of microtubule dynamic instability by the +TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued, Biochemistry, 47, 779-786. Ray A, Okouneva T, Manna T, Miller HP, Schmid SM, Art.haud L, Jordan MA, Wilson L. Mechanism of action of the microtubule targeted antimitotic depsipeptide Tasidotin (formerly ILX 651) and its major metabolite, Tasidotin C-carboxylate. (2007) Cancer Research, 67, 3767-3776. Manna T, Grenningloh G, Miller HP, Wilson L. The Oncoprotein18 family protein SCG10 differentially regulates plus and minus end dynamics of microtubule at steady state in vitro: Implications for its role in neurite outgrowth. (2007) Biochemistry, 46, 3543-3552. Manna T, Thrower D, Miller HP, Curmi P, Wilson L. (2006) Oncoprotein18 strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro. Journal of Biological Chemistry, 281: 2071-2078. Mohan R, Banerjee M, Ray A, Manna T, Wilson L, Owa T, Bhattacharyya B, Panda D. (2006) Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation. Biochemistry, 45, 5440-5449. Jordan MA, Kamath K, Manna T, Okouneva T, Miller HP, Davis C, Littlefield B, Wilson L. (2005) The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Molecular Cancer Therapeutics, 4:1086-1095 Sarkar T, Mitra G, Gupta S, Manna T, Poddar A, Panda D, Das KP, Bhattacharyya B. (2004) MAP2 prevents protein aggregation and facilitates reactivation of unfolded enzymes. European Journal of Biochemistry. 271(8):1488-96. Manna T, Sarkar T, Poddar A, Roychowdhury M, Das KP, Bhattacharyya B. Chaperone-like activity of tubulin. binding and reactivation of unfolded substrate enzymes. (2001) Journal of Biological Chemistry, 276, 39742-39747. Sarkar T, Manna T, Bhattacharyya S, Mahapatra P, Poddar A, Pena J, Solana R, Tarazona R, Roy S, Bhattacharyya B. Role of the carboxy-termini of tubulin on its chaperone-like activity. (2001) Proteins: Structure, Function, and Genetics 44, 262-269. Pal D, Mahapatra P, Manna T, Chakraborty P, Bhattacharyya B, Banerjee A, Basu G, Roy S. Conformational properties of alpha-tubulin tail peptide: implications for tail-body interaction. (2001) Biochemistry 40, 15512-15519. Roychowdhury M, Sarkar N, Manna T, Bhattacharyya S, Sarkar T, Basusarkar P, Roy S, Bhattacharyya B. Sulfhydryls of tubulin. A probe to detect conformational changes of tubulin (2000), European Journal of Biochemistry 267, 3469-3476.

Global Scientific Words in Biochemistry