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Dr Ramanathan Natesh

Assistant Professor
Department of Biology
Indian Institute of Science Education and Research Thiruvananthapuram
India

Professor Bioinformatics and Systems Biology
Biography

Aug 2010-Present : DBT Ramalingaswami Fellow and Assistant Professor at IISER-TVM (Thiruvananthapuram, INDIA.) Wellcome Trust AT Fellow (PI on grant) (2007 – 2010): School of Biological Sciences, Birkbeck College, University of London (London, UK), (Host: Professor Helen Saibil (F.R.S, FMedSci)) HFSP ST fellow (2006 – 2007): Department of Physiology, University of Toronto(Toronto, CANADA), Postdoctoral Fellow, (2005 – 2006): IGBMC(Strasbourg,FRANCE), Research Scientist, (2004 – 2005): ICGEB (New Delhi, INDIA), Research Officer, (2001 – 2003):University of Bath (Bath, UK),

Research Intrest

Crystallography and CryoEM structural studies of complexes of signal transduction proteins in Cardiovascular Disease, proteins involved in Mycobacterium Tuberculosis. Life shows its spectacular colours in its myriad diversity, yet life shares certain fundamental common elements like proteins, DNA etc. Students and researchers can build upon kn

List of Publications
Natesh R. (2014). Crystallography beyond Crystals: PX and SPCryoEM. Resonance, 19, 1177-1196. 15) Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP. (2007). Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. J. Biol. Chem., 282, 33064-33075. 14) Watermeyer JM, Sewell BT, Schwager SL, Natesh R, Corradi HR, Acharya KR, Sturrock ED. (2006). Structure of testis ACE glycosylation mutants and evidence for conserved domain movement. Biochemistry, 45, 12654-12663. 13) Balyasnikova IV, Woodman ZL, Albrecht II RF, Natesh R, Acharya KR, Sturrock ED, Danilov SM. (2005). The localization of an N-domain region of Angiotensin-Converting Enzyme involved in the regulation of Ectodomain Shedding using monoclonal antibodies J. Proteome Res., 4, 258-267. 12) Lloyd MD, Pederick RL, Natesh R, Woo LW, Purohit A, Reed MJ, Acharya KR, Potter BV. (2005) Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent. Biochem J. 385, 715-720. 11) Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR. (2004). Structural Details on the Binding of Anti-hypertensive Drugs Captopril and Enalaprilat to human testicular Angiotensin Converting Enzyme. Biochemistry, 43, 8718-8724. 10) Sturrock ED, Natesh R, van Rooyen J and Acharya KR (2004). Structure of Angiotensin-I converting enzyme. Cellular and Molecular Life Sciences (CMLS), 61, 2677-2686.

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