Dr. Dean Befus, PhD Professor, Astra-Zeneca Canada Inc., Chair in Asthma Research, Division of Pulmonary Medicine, Department of Medicine, Director, Alberta Asthma Centre. Dr. Dean Befus, PhD Professor, Astra-Zeneca Canada Inc., Chair in Asthma Research, Division of Pulmonary Medicine, Department of Medicine, Director, Alberta Asthma Centre.

Functions and regulation of mast cells in allergic and other inflammatory conditions: We study mast cell activation and novel pathways that may be targets for new anti-allergic and anti-inflammatory agents. Our studies are focused on the molecular mechanisms of the regulation of mast cells. In particular, we are investigating the production of nitric oxide production by mast cells and its functions in allergy and innate immunity.  A major focus is on the interaction between mast cells and airway epithelial cells in defense against influenza A. The neuro-endocrine-immunologic network in inflammation: In collaboration with colleagues at the University of Calgary, we have defined novel peptides derived from a prohormone, that is controlled by the sympathetic nervous system and plays important roles in the regulation of inflammatory responses, such as in asthma.  Novel anti-inflammatory drugs have been developed and completed phase I and phase 2a clinical testing on asthma.  We are translating this work from animal models into humans. As Director of the Alberta Asthma Centre, I also have broad interests in asthma; ranging from its management to the development, implementation and evaluation of education programs for adults and children, their families and health care professionals.