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Donna M. Driscoll

Staff
Cellular and Molecular Medicine
Cleveland Clinic Lerner Research Institute
United States of America

Professor Medical Sciences
Biography

Selenium is an essential trace element that exerts a number of important health benefits. The nutritional requirement for this micronutrient is likely due to its function in selenoproteins, which contain selenium as selenocysteine, the 21rst amino acid. Many selenoproteins are enzymes that contain selenocysteine at their active site.

Research Intrest

RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

List of Publications
Miniard, AC, Middleton, LM, Budiman ME, Gerber CA, Driscoll, DM (2010) Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression. Nucleic Acids Res., 38: 4807-4820.
Azevedo, M (2010) Selenoproteins-related disease in a young girl caused by nonsense mutations in the SECISBP2 gene. J. Clin. Endo. & Metab. 95:4066-4071.
Budiman, ME, Bubenik JL, Driscoll, DM (2011) Identification of a molecular signature for the eIF4a3:SECIS interaction. Nucleic Acids Res 39:7730-7739.

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