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Dolapo Adedeji

Assistant Professor
Natural Sciences
Elizabeth City State University
United States of America

Professor Biochemistry
Biography

Ph.D. (Chemistry with concentration in Biochemistry), Auburn University, Auburn. Alabama B.Sc. (Chemical Sciences), University of Agriculture, Abeokuta, Ogun State. Nigeria. Dr. Dolapo Adedeji is an assistant professor in the department of Pharmacy and Health Professions. She also serves as the program coordinator for the Bachelor of Science in Pharmaceutical Sciences (BSPS)program.

Research Intrest

Dr. Dolapo Adedeji's research interests include the development of anti-infective drugs that can be used in the treatment of the diseases caused by bacterial infections and malaria (pathogenic organisms). The rapidly increasing resistance developed by many pathogenic organisms to most of the currently available drugs is posing a serious health concern. There is a need for the development of new drugs for the treatment of the diseases caused by these pathogens. This should exploit target mechanisms that are different from commercial drugs that are currently available. It is important to understand the operation of the metabolic pathways that exist in these pathogens so as to find the appropriate target that can be used in the development of drugs against them. One of such pathways is the 1-deoxy-D-xylulose-5-phosphate (DOXP) for isoprene biosynthesis. This is a new and unique target for the development of anti-infective drugs.

List of Publications
Hinton, B. V., Adedeji, D. A., & Payne, G. E. (2017). In-Vitro Antiproliferative Analysis of Metformin Hydrochloride on Androgen-Sensitive, LNCAP and Androgen-Insensitive, PC-3 Human Prostate Cancer Cell Lines. Pharmacology & Pharmacy, 8(03), 85.
Brandy, Y., Ononiwu, I., Adedeji, D., Williams, V., Mouamba, C., Kanaan, Y., ... & Bakare, O. (2009, August). Synthesis, characterization, and anticancer evaluation of aryl-substituted-oxazolo-1, 4-naphthoquinone derivatives. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 238). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Brandy, Y., Ononiwu, I., Adedeji, D., Williams, V., Mouamba, C., Kanaan, Y., ... & Bakare, O. (2012). Synthesis and cytotoxic activities of some 2-Arylnaphtho [2, 3-d] oxazole-4, 9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines. Investigational new drugs, 30(4), 1709-1714.
Adedeji, D., Hernandez, H., Wiesner, J., Köhler, U., Jomaa, H., & Duin, E. C. (2007). Possible direct involvement of the active‐site [4Fe–4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP. FEBS letters, 581(2), 279-283.
Xu, W., Lees, N. S., Adedeji, D., Wiesner, J., Jomaa, H., Hoffman, B. M., & Duin, E. C. (2010). Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions. Journal of the American Chemical Society, 132(41), 14509-14520.

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