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Dennis J. Stuehr

Associate Staff
Pathobiology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Pathology
Biography

Our laboratory studies nitric oxide (NO) biosynthesis in mammals. NO is made by an enzyme named NO synthase, and is involved in many aspects of cell function and disease, including signal transduction in the brain, control of blood pressure and heart rate, gastric motility, oxygen delivery, immunologic destruction of tumor cells and microbes, infertility, impotence, and stroke.

Research Intrest

Inflammation; Nitric oxide; Heme transport; Soluble guanylate cyclase; Electron transfer

List of Publications
anda K, Haque M, Garcin-Hosfield E, Durra D, Getzoff E, Stuehr DJ. Surface charge interactions of the FMN module govern NO synthase. J Biol Chem 2006 28:36819-27
Haque M, Panda K, Tejero J, Aulak K, Fadlalla M, Mustovich A, Stuehr DJ. A connecting hinge represses the activity of endothelial NO synthase. PNAS 2007 104:9254-9
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