Dr. Madtes is a pulmonary and critical care specialist with over 28 years of experience in lung cancer early detection, lung cancer screening, minimally invasive diagnostic procedures for lung cancer diagnosis and treatment of pulmonary complications related to oncologic diseases. His education and training include a B.A. from Gettysburg College in 1974, an M.D. from the University of Pittsburgh in 1979, residency training in internal medicine at the University of Rochester in 1983 and fellowship training in pulmonary and critical care medicine at the University of Washington in 1986. Dr. Madtes has distinguished himself as a physician, researcher and teacher. He is a prolific researcher, publishing over 64 refereed articles and 4 book chapters since 1984. He is the director of the Lung Cancer Early Detection and Prevention and the Lung Cancer CT Screening Programs at the Seattle Cancer Care Alliance. He is a full member in the Clinical Research Division of the Fred Hutchinson Cancer Research Center and section head of Pulmonary and Critical Care Medicine at the Fred Hutchinson Cancer Research Center. He has been honored with Seattle Magazine’s Top Doctors Award (2013, 2014, 2015).

The focus of research is on the cellular and molecular mechanisms responsible for normal alveolar development and repair and for the fibroproliferative response that results in pulmonary fibrosis. Two primary projects: are 1) the identification of growth factors that regulate the cellular proliferation and extracellular matrix remodeling in the injured alveolus and in the developing lung; and 2) the identification of matrix metalloproteinases and tissue inhibitors of metalloproteinases responsible for extracellular remodeling in lung fibrosis.