David Golan

Professor
Department of Biological Chemistry and Molecular Pharmacolog
Harvard Medical School
United States of America

Professor Molecular Biology
Biography

Harvard Medical School in 2014, after serving as dean for graduate education since 2008. He is a professor in the HMS Department of Biological Chemistry and Molecular Pharmacology, where his laboratory applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. He is also the HMS George R. Minot Professor of Medicine and senior physician in the Department of Medicine at Brigham and Women's Hospital and the Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician-teacher. Golan founded the core course in pharmacology in the New Pathway curriculum at HMS and directed it from 1989 to 2006. He currently co-directs a translational pharmacology course in the Therapeutics Graduate Program, the Leder Human Biology and Translational Medicine Graduate Program, and the Master of Medical Sciences in Clinical Investigation at HMS. The curriculum is guided by the principle that drug mechanisms are best understood in the context of the physiological, biochemical and pathophysiological pathways on which the drugs act. By translating this principle into his course design, Golan has provided thousands of Harvard students with a foundation for lifelong learning in pharmacology and therapeutics. Golan is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 1st Edition (2005), 2nd Edition (2008), 3rd Edition (2011) and 4th Edition (2016) and co-editor of the Principles of Pharmacology Workbook (2008); both texts are authored with the same guiding principle as the HMS pharmacology courses. The 3rd Edition of Principles of Pharmacology won first prize in pharmacology in the British Medical Association Medical Book Award competition (2012). In his role as dean for basic science and graduate education, Golan advises and assists the dean of the faculty of medicine on the articulation, design and implementation of a strategic vision for HMS’s basic and social science enterprise, including cross-departmental, cross-School, and cross-institutional initiatives and collaborations.

Research Intrest

Cellular imaging of protein-protein interactions Molecular interactions in erythroid cell membranes Lymphocyte-erythrocyte adhesion in sickle cell disease Molecular interactions in T-cell adhesion

List of Publications
Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov. 2008; 7:21-39. Review.
Karnchanaphanurach P, Mirchev R, Ghiran I, Asara JM, Papahadjopoulos-Sternberg B, Nicholson-Weller A, Golan DE. C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. J Clin Invest. 2009; 119:788-801. Epub 2009 Mar 2.
Bajmoczi M, Gadjeva M, Alper SL, Pier G, Golan DE. Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol. 2009; 297:C263-277. Epub 2009 Apr 22.
Cairo CW, Das R, Albohy A, Baca QJ, Pradhan D, Morrow JS, Coombs D, Golan DE. Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells. J Biol Chem. 2010; 285:11392-11401. Epub 2010 Feb 17.