David E. Sosnovik

Associate Professor
Departmaent of Medicine
Harvard Medical School
United States of America

Professor Cardiology
Biography

Dr Sosnovik is an Associate Professor of Medicine at Harvard Medical School and an Attending Cardiologist at the Massachusetts General Hospital. His clinical interests lie in general cardiology, heart failure, valvular and congenital heart disease. Dr Sosnovik's principal research interests lie in the development of novel cardiac imaging modalities. Prior to coming to the MGH to begin his cardiology fellowship, he spent several years as a research fellow in the department of Physics at Washington University. After completing his general cardiology training at MGH, Dr Sosnovik pursued advanced training in cardiovascular MRI at the MGH. He also trained in two large research centers at the MGH: The Martinos Center for Biomedical Imaging and the Center for Molecular Imaging Research. Dr Sosnovik is currently the Director of the Program in Cardiovascular Imaging in the MGH-MIT Martinos Center for Biomedical Imaging. His research focuses on molecular imaging, diffusion MRI of the myocardium, high field MRI, the development of new contrast mechanisms and rapid imaging techniques, and novel platforms for advanced imaging in humans. Dr Sosnovik has published over 90 papers in these fields and has been continuously funded by the national institutes of health (NIH) for over 10 years. He is a member of the affiliated faculty in the Harvard-MIT division of Health Sciences and Technology (HST) and plays an active role in teaching in both the MIT and Harvard communities.

Research Intrest

Dr Sosnovik is currently the Director of the Program in Cardiovascular Imaging in the MGH-MIT Martinos Center for Biomedical Imaging . His research focuses on molecular imaging, diffusion MRI of the myocardium, high field MRI, the development of new contrast mechanisms and rapid imaging techniques, and novel platforms for advanced imaging in humans. Dr Sosnovik has published over 90 papers in these fields and has been continuously funded by the national institutes of health (NIH) for over a decade. He has served as an associate editor and/or a member of editorial board of several prominent journals including Radiology, Nanomedicine and Circulation-Cardiovascular Imaging. He is a member of the affiliated faculty in the Harvard-MIT division of Health Sciences and technology (HST) and plays an active role in teaching in both the MIT and Harvard communities.

List of Publications
Stoeck CT, Kalinowska A, von Deuster C, Harmer J, Chan RW, Niemann M, Manka R, Atkinson D, Sosnovik DE, Mekkaoui C, Kozerke S. Dual-phase cardiac diffusion tensor imaging with strain correction. PLoS One. 2014; 9(9):e107159. PMID: 25191900; PMCID: PMC4156436.
Cui J, Kessinger CW, McCarthy JR, Sosnovik DE, Libby P, Thadhani RI, Jaffer FA. In vivo nanoparticle assessment of pathological endothelium predicts the development of inflow stenosis in murine arteriovenous fistula. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):189-96. PMID: 25395614; PMCID: PMC4270948 [Available on 01/01/16].
Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 2014 Dec 10; 6(266):266ra170. PMID: 25504881; PMCID: PMC4360984.
Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L. Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug. Nanoscale. 2015 Feb 14; 7(6):2255-9. PMID: 25572921; PMCID: PMC4312233.
Thoonen R, Ernande L, Cheng J, Nagasaka Y, Yao V, Miranda-Bezerra A, Chen C, Chao W, Panagia M, Sosnovik DE, Puppala D, Armoundas AA, Hindle A, Bloch KD, Buys ES, Scherrer-Crosbie M. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. J Mol Cell Cardiol. 2015 Jul; 84:202-11. PMID: 25968336; PMCID: PMC4470477.
Sosnovik DE. Seeing What We Build--The Need for New Imaging Techniques in Myocardial Regeneration. J Am Heart Assoc. 2015 Jul 27; 4(7). PMID: 26215973; PMCID: PMC4608098.
Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13002-6. PMID: 26368132; PMCID: PMC4754124 [Available on 10/26/16].
Mekkaoui C, Reese TG, Jackowski MP, Bhat H, Sosnovik DE. Diffusion MRI in the heart. NMR Biomed. 2017 Mar; 30(3). PMID: 26484848.
Zou L, Chen HH, Li D, Xu G, Feng Y, Chen C, Wang L, Sosnovik DE, Chao W. Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis. Crit Care Med. 2015 Nov; 43(11):2303-12. PMID: 26335111.
Panagia M, Chen YC, Chen HH, Ernande L, Chen C, Chao W, Kwong K, Scherrer-Crosbie M, Sosnovik DE. Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance. NMR Biomed. 2016 Jul; 29(7):978-84. PMID: 27226402; PMCID: PMC4912044 [Available on 07/01/17].
Goergen CJ, Chen HH, Sakadžic S, Srinivasan VJ, Sosnovik DE. Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy. Physiol Rep. 2016 Sep; 4(18). PMID: 27650248.
Mekkaoui C, Reese TG, Jackowski MP, Cauley SF, Setsompop K, Bhat H, Sosnovik DE. Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology. 2017 Mar; 282(3):850-856. PMID: 27681278.
Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE. Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury. Theranostics. 2017; 7(4):814-825. PMID: 28382156.
Dos Santos Ferreira D, Jesus de Oliveira Pinto BL, Kumar V, Cardoso VN, Fernandes SO, Souza CM, Cassali GD, Moore A, Sosnovik DE, Farrar CT, Leite EA, Alves RJ, de Oliveira MC, Guimarães AR, Caravan P. Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine. 2017 Jul; 13(5):1693-1701. PMID: 28343016.
Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Chen KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. PMID: 28483998.