Dr. David  Donze  is currently working as a Professor  in the Department of Department of Biological Sciences, Louisiana State University , USA. His research interests includes Deciphering basic mechanisms of gene expression, DNA binding proteins, chromatin structure,extra-transcriptional functions,eukaryotic transcription complexes. He is serving as an editorial member and reviewer of several international reputed journals. Dr. David  Donze  is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Deciphering basic mechanisms of gene expression, DNA binding proteins, chromatin structure,extra-transcriptional functions,eukaryotic transcription complexes.

Research in my laboratory is aimed at deciphering basic mechanisms of gene expression as governed by DNA binding proteins and chromatin structure. We use the yeast Saccharomyces cerevisiae as a model system, as it is a simple eukaryote that can be easily manipulated both genetically and biochemically in the laboratory. Many basic molecular and biochemical mechanisms elucidated in yeast have been extrapolated to other eukaryotes. Current research in my laboratory focuses on what we refer to as “extra-transcriptional functions” of the RNA Polymerase III system in eukaryotes. RNA polymerase III (Pol III) is one of three eukaryotic transcription complexes, and was identified as the enzyme responsible for synthesis of transfer RNA and a limited number of other small RNAs. Pol III transcription at tRNA genes (tDNAs) requires the binding of two transcription factor complexes, TFIIIC and TFIIIB, which then recruit the Pol III enzymatic transcription machinery to form large and stable macromolecular complexes on chromosomes.