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David Adams

Senior Group Leader
cancer genes and genetic interactions
Weill Cornell Medical College
United Kingdom

Professor Infectious Diseases
Biography

David uses DNA sequencing of patients and genetic screens in human cells and mice to identify cancer genes and genetic interactions. Dr. David Adams and his group study the mechanisms of cancer development, particularly skin cancer (melanoma) and colorectal cancer. They sequence DNA from families with a high incidence of cancer, and also tumours from patients to understand why some people are at greater risk of tumour development and how cancers evolve. The group also performs functional studies in cultured cells and in mice to understand how factors such as DNA mutations and the immune system influence tumour growth.

Research Intrest

cancer genes and genetic interactions

List of Publications
Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes. Rashid M, Fischer A, Wilson CH, Tiffen J, Rust AG et al. The Journal of pathology 2016;238;1;98-108 PUBMED: 26414517; PMC: 4832337; DOI: 10.1002/path.4643
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Perna D, Karreth FA, Rust AG, Perez-Mancera PA, Rashid M et al. Proceedings of the National Academy of Sciences of the United States of America 2015;112;6;E536-45 PUBMED: 25624498; PMC: 4330752; DOI: 10.1073/pnas.1418163112
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG et al. Nature 2015;517;7535;489-92 PUBMED: 25363767; PMC: 4304785; DOI: 10.1038/nature13898
Experts in United Kingdom
Ian Weeks Dr Steve Riley M H FERRI ALIABADI Simon Jones DR GIULIANOALLEGRI Michael Owen PETER BEARMAN Dr Richard Adams DR PAUL BRUCE Robert Lee Mansour Moniri Paul Hackett Dr Ameer Al-Nemrat Dr Jawed Qureshi Miss Sarah Catmur Mark Banfield Janneke Balk Arya Assadi Langroudi Rob Field George Lomonossoff Tony Maxwell Sarah OConnor Robert Sablowski Stephen de Mora Susan Brind View More