Damien S. K. Samways

Assistant Professor
Department of Biology
Clarkson University
United States of America

Professor Microbiology
Biography

He have completed his Ph.D. from Department of Pharmacology, University of Bristol, (2003)

Research Intrest

Ion channels are specialized membrane spanning proteins that open and form ion permeable pores in response to various stimuli, including binding by diffusible ligands. Many of these ion channels are located on the plasma membrane enveloping all cells, and by conducting the movement of ions such as Na+, K+, and Ca2+ can regulate a diversity of intracellular processes, such as neuronal action potential propagation, secretion, muscle contraction, and gene expression. My current research interests are focused on elucidating the structure and function of ion channels that are activated in response to extracellular ligands, such as neurotransmitters. Understanding the molecular basis by which ion channels are activated and consequently select and conduct ions is an important step towards designing new drugs capable of targeting these proteins for therapeutic purposes. Some of these ion channels have been shown to transport relatively large ionic species into cells, and an additional goal of the laboratory is to see whether this property can be exploited in order to facilitate drug delivery into tumor cells.

List of Publications
Z. Lin, P. Perez, J-J. Liu, J.H. Shin, K.L. Hyrc, D.S.K Samways, T.M. Egan, M.C. Holley, and J. Bao (2012). Reprogramming of single-cell-derived mesenchymal stem cells into hair cell-like cells. Otol. Neurotol. 33, 1648-55
D.S.K. Samways, Z. Li and T.M. Egan (2014). (Invited review) Principles and properties of ion flow in P2X receptors. Front. Cell. Neurosci. 5;8:6. doi: 10.3389/fncel.2014.00006
D.S.K. Samways (2014). Applications for mass spectrometry in the study of ion channel structure and function. Adv Exp Med Biol. 806, 237-61. doi: 10.1007/978-3-319-06068-2_10.
L. Zhang, H. Xu, Y. Jie, C. Gao, W. Chen, S. Yin, D.S.K. Samways, and Z. Li (2014). Involvement of Residue L214 of P2X4 Receptor in ATP Binding and Channel Gating. J. Biol. Chem. 53, 3012-9
K.L. Poetz, H.S. Mohammed, G. Liddil, D.S.K. Samways, and D.A. Shipp (2014). A Study of the Degradation Product from Polyanhydrides Synthesized by Thiol-Ene Polymerization. Biomacromolecules. 15, 2573-82