Assistant Professor
Department of Biology
Clarkson University
United States of America
He have completed his Ph.D. from Department of Pharmacology, University of Bristol, (2003)
Ion channels are specialized membrane spanning proteins that open and form ion permeable pores in response to various stimuli, including binding by diffusible ligands. Many of these ion channels are located on the plasma membrane enveloping all cells, and by conducting the movement of ions such as Na+, K+, and Ca2+ can regulate a diversity of intracellular processes, such as neuronal action potential propagation, secretion, muscle contraction, and gene expression. My current research interests are focused on elucidating the structure and function of ion channels that are activated in response to extracellular ligands, such as neurotransmitters. Understanding the molecular basis by which ion channels are activated and consequently select and conduct ions is an important step towards designing new drugs capable of targeting these proteins for therapeutic purposes. Some of these ion channels have been shown to transport relatively large ionic species into cells, and an additional goal of the laboratory is to see whether this property can be exploited in order to facilitate drug delivery into tumor cells.