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Daisuke Hagiwara

Assistant Professor
Division of Clinical Research
Chiba University
Japan

Professor Clinical Sciences
Biography

Assistant Professor at Medical Mycology Research Center, Chiba University, Research projects on Project to Link Basic Sciences and Clinical Medicine, Molecular biology, Microbiology.

Research Intrest

Stress response signaling systems, mechanism for responses to environment and molecular mechanisms for azole-resistance in pathogenic fungi.

List of Publications
Hagiwara D, Takahashi H, Fujimoto M, Sugawara M, Misawa Y, Gonoi T, Itoyama S, Watanabe A, Kamei K: Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan. J Infect Chemother, 22:577-579, 2016.
Hagiwara D, Sakamoto K, Abe K, Gomi K. Signaling pathways for stress responses and adaptation in Aspergillus species: Stress biology in the post-genomic era. Biosci Biotechnol Biochem, 80:1667-1680, 2016.
Hagiwara D, Watanabe A, Kamei K: Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene. Scientific Reports, 6:38833, 2016.
Hagiwara D, Miura D, Shimizu K, Paul S, Ohba A, Gonoi T, Watanabe A, Kamei K, Shintani T, Moye-Rowley WS, Kawamoto S, Gomi K: A novel Zn2-Cys6 transcription factor AtrR plays a key role in an azole resistance mechanism of Aspergillus fumigatus by co-regulating cyp51A and cdr1B expressions. PLoS Pathogens, 13(1):e1006096, 2017.

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