Clifton O. Bingham

Professor
Medicine - Rheumatology
Johns Hopkins University
United States of America

Professor Orthopaedics
Biography

Dr. Clifton Bingham is a Professor of Medicine, Director of the Johns Hopkins Arthritis Center, Director of the Center for Patient-Centered Outcomes Research in Rheumatology, Deputy Director for Research in the Division of Rheumatology, and Co-Director of the Rheumatic Diseases Research Core Center. He received his M.D. from Columbia University, where he also completed his Internal Medicine residency. He trained as a Fellow in both Rheumatology and in Allergy and Clinical Immunology at the Brigham and Women’s Hospital. Before coming to Hopkins in 2005, he was on faculty at NYU Hospital for Joint Diseases, where he founded a pioneering clinical and translational research center in rheumatology. He now directs the Johns Hopkins Arthritis Center, a group of 8 rheumatologists, 2 nurses, and a large clinical and research staff that sees more than 4500 patient visits each year, an integrates research with clinical care. His clinical interests are in the care of people living with Rheumatoid Arthritis (RA) and other forms of inflammatory arthritis. Dr. Bingham’s research experience has been diverse, and across the research continuum from bench to bedside. His early work focused on understanding the cytokine regulation of inflammatory mediator generation operative in rheumatologic and allergic diseases. He conducted prior translational research to better understand the role of initiating and amplifying pathways in RA, and has ongoing collaborations with several basic researchers to identify biomarkers for improved patient phenotyping and outcome prediction. Additional multidisciplinary clinical and translational work has focused on the role of periodontal disease and oral bacteria as triggers of RA. In the realm of clinical research, he has served as principal investigator and helped to design and analyze a number of NIH and industry-sponsored clinical trials of multiple agents in early to late phases of development for RA, psoriatic arthritis, and osteoarthritis. He has led several studies of the effects of biological and immunomodulatory therapies on responses to immunizations. A large amount of his current research is focused in the area of patient centered outcomes research, including patient reported outcome development, validation, and integration in clinical care. He serves as a member of the Executive Leadership Committee for the international Outcome Measures in Rheumatology (OMERACT) methodology group. He has authored more than 120 original research articles, reviews, and editorials, and 12 book chapters. He has served as a Co-Editor for the journal of the American College of Rheumatology, Arthritis and Rheumatology, and as a reviewer for a number of rheumatology journals and national and international grant reviews.

Research Intrest

Arthritis Therapeutics; Clinic Trial outcomes in Arthritis; Oral Health in Arthritis; Patient Reported Outcomes; Rheumatoid Arthritis

List of Publications
Bingham CO 3rd, Alten R, DeWit MP. The Importance of Patient Participation in Measuring Rheumatoid Arthritis Flares. Ann Rheum Dis, 2012;71:7 1107-1109.
Bartlett SJ, Bykerk VB, Cooksey R, Choy EH, Alten R, Christensen R, Furst DR, Guillemin F, Halls S, Hewlett S, Leong AL, Lyddiatt A, March L, Monte P, Orbai AM, Pohl C, Voshaar MS, Woodworth TG, Bingham CO 3rd. Feasibility and domain validation of RA flare core domain set: A report of the OMERACT Flare working group. J Rheumatol 2015 Feb 15. pii: jrheum.141169.
Orbai AM, Smith KC, Bartlett SJ, DeLeon E, Bingham CO 3rd. "Stiffness has different meanings, I think, to everyone." Examining stiffness from the perspective of people living with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Nov; 66(11):1662-72.