Biography

Ciro Cecconi completed his Ph.D. in Molecular and Cell Biology University of California, Berkeley, USA - December 2003. He worked as a Supervisor: Prof. Carlos J. Bustamante, Department of Physics and Molecular & Cell Biology. Thesis Title: Studies of the Mechanical Unfolding and Refolding of RNase H and T4 lysozyme.

Research Intrest

Single molecule manipulation techniques, Mechanical properties of tertiary and secondary protein structures, Folding and misfolding pathways of individual protein molecules, Kinetics and thermodynamics of fluctuations between different molecular conformations, Protein energy landscapes, Molecular dynamics simulations.

List of Publications
Heidarsson PO, Valpapuram I, Camilloni C, Imparato A, Tiana G, et al. (2012) A highly compliant protein native state with a spontaneous-like mechanical unfolding pathway. J Am Chem Soc 134: 17068-17075.
Heidarsson PO, Otazo MR, Bellucci L, Mossa A, Imparato A, et al. (2013) Single-molecule folding mechanism of an EF-hand neuronal calcium sensor. Struct 21: 1812-1821.
Heidarsson PO, Naqvi MM, Otazo MR, Mossa A, Kragelund BB, et al. (2014) Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1. Proc Natl Acad Sci 111: 13069-13074.

Global Scientific Words in Chemistry