Christopher Hill, D.Phil., is a distinguished professor in the Department of Biochemistry at the University of Utah School of Medicine. He serves as department co-chair jointly with Wes Sundquist, holds the H.A. and Edna Benning Medical Society Chair, and is a member of the Nuclear Control of Cell Growth and Differentiation Program.   The Hill Lab uses structural and biochemical approaches to study how proteins function. This approach is applied to numerous targets that are relevant to cancer mechanisms. Studies on proteasome and protein quality control seek to understand mechanisms in a validated cancer therapeutic target. Studies of HIV-host interactions and the ESCRT pathway have led into mechanistic studies on how cells divide, and may inform new approaches to prevent the uncontrolled proliferation characteristic of cancers. Studies on nucleosome remodeling and reorganizing complexes advance understanding of mechanisms of gene expression, which may offer insights to the genetic defects that underlie progression toward cancer.   Hill received his BA and D.Phil. from the University of York, England. He then completed a postdoctoral fellowship at the University of California at Los Angles. Hill presents and publishes widely and has received numerous research fellowships and grants.

Structural Biology Proteasome Activation and Regulation Protein Quality Control HIV Structure and Host Interactions ESCRT Pathway Nucleosome Remodeling and Reorganization