Christopher Brigham

Assistant Professor
Microbiology
University of Massachusetts Dartmouth
United States of America

Professor Microbiology
Biography

  Ph.D. in Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA B.S. in Chemical Engineering, Villanova University, Villanova, PA

Research Intrest

Sustainable, bio-based chemicals and materials are becoming highly sought after in many spheres of human activity. Many compounds that were originally produced by industrial chemical methods can now be produced by microorganisms. The discipline of metabolic engineering allows us to construct metabolic pathways to synthesize value added products from surplus or waste carbon feedstocks. Using the bacterium Ralstonia eutropha (a.k.a Cupriavidus necator) and other industrially relevant species, we produce materials like bioplastics from plant oils and carbon-containing waste streams, and we can design metabolic pathways that allow the bacterium to produce compounds like biofuels and fine chemicals. We can then use bioengineering to scale up synthesis of these compounds and develop a production process and measure its productivity. Also, the understanding of the metabolism of organisms like R. eutropha in nature can help us rationally design a production strain with high productivity in mind.   

List of Publications
R. Jüngert, Janina & Borisova-Mayer, Marina & Mayer, Christoph & Wolz, Christiane & Brigham, Christopher & Sinskey, Anthony & Jendrossek, Dieter. (2017). Absence of ppGpp Leads to Increased Mobilization of Intermediately Accumulated Poly(3-hydroxybutyrate) (PHB) in Ralstonia eutropha H16. Applied and Environmental Microbiology. 83. AEM.00755-17. 10.1128/AEM.00755-17.
Brigham, Christopher & R. Speth, Daan & Rha, ChoKyun & Sinskey, Anthony. (2017). Correction for Brigham et al., “Whole-Genome Microarray and Gene Deletion Studies Reveal Regulation of the Polyhydroxyalkanoate Production Cycle by the Stringent Response in Ralstonia eutropha H16”. Applied and Environmental Microbiology. 83. e01216-17. 10.1128/AEM.01216-17.
Kehail, Abdulrahman & d.Fazlay Rabbi, M & Bach, Nicholas & Chalivendra, Vijaya & Brigham, Christopher. (2017). Modeling mechanical properties of polyhydroxyalkanoate during degradation in animal tissue: Modeling Mechanical Properties of Polyhydroxyalkanoate. Polymers for Advanced Technologies. . 10.1002/pat.4076.
Corrigendum to “Experimental evolution and gene knockout studies reveal AcrA-mediated isobutanol tolerance in Ralstonia eutropha” [J Biosci Bioeng 122 (2016) 64–69]