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Christine McDonald

Associate Staff
Pathobiology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Pathology
Biography

Vascular complications of diabetes are the main and a long-standing interest of my group. Hyperglycemia is an independent risk-factor for development of macrovascular and microvascular complications. 

Research Intrest

Anti-bacterial immune responses; inflammatory bowel disease; Crohn's disease; NOD2; host defense; innate immunity

List of Publications
Richmond A.L., et al. The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Anti-Bacterial Function in Human Intestinal Epithelial Cells. Gastroenterology 2012; 142:1483-1492.
Homer C.R., et al. ATG16L1 and NOD2 interact in an autophagy-dependent, anti-bacterial pathway implicated in Crohn’s disease pathogenesis. Gastroenterology 2010; 139:1630-1641.
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