Charles Lee

Associate Professor
Comparative Biomedical Sciences
Louisiana State University
United States of America

Biography

He was born and raised in Flagstaff, Arizona and graduated as valedictorian from Flagstaff High School. While still in high school, I concurrently attended Northern Arizona University, where I completed the chemistry major course requirements and conducted research on photoconductive organic polymer systems. Thereafter, I attended the California Institute of Technology, where I was a member of Lloyd House and graduated with honors in chemistry and biology. For graduate school at the University of California at Berkeley, I worked under the mentorship of the late Prof. Jeffery A. Winer. My dissertation focused on the functional organization of convergent neural circuits in the auditory forebrain. Afterwards, I received an NIH Kirschstein NRSA Fellowship to work with Prof. S. Murray Sherman at the University of Chicago, where I was a Research Associate (Assistant Professor). Since 2011, I have been on the faculty at the LSU School of Veterinary Medicine.

Research Intrest

My laboratory is interested in understanding the neural principles underlying the sensory and cognitive functions of the brain using the central auditory system as a model. We study the anatomical circuits and the physiological properties of sensory synapses in the midbrain, thalamus, and cortex by recording from neurons in response to pharmacological activation, electrical stimulation, optogenetic manipulation, or photostimulation by uncaging of glutamate. Morphological correlates are sought using neuroanatomical methods, such as anterograde and retrograde tract-tracing, cell-type specific viral tracers, and intracellular filling of recorded neurons. From our studies, we wish to derive the rules governing the emergent properties of neuronal ensembles and their roles in regulating behavior. My research also addresses how alterations to these central sensory pathways give rise to various mental health disorders. In particular, we are focusing on the neural circuit basis of autism spectrum disorder and schizophrenia. Our long-term objectives are to understand how aberrant neural circuit organization results in the emergent core behavioral deficits observed in these conditions. We expect that this research will illuminate the potentially important role of these neural networks in these conditions and as prospective therapeutic targets.

List of Publications
Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy, Ogundele , Olalekan; Ebenezer, Philip; Lee, Charles; Francis, Joseph, 2017, Neuroscience , Volume: 353, Pages: 147-165
Thalamic dopaminergic neurons project to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit, Ogundele , Olalekan; Lee, Charles; Francis, Joseph, 2017, The Anatomical Record , Volume: 300, Number: 7, Pages: 1307-1314
Systemic sympathoexcitation was associated with paraventricular hypothalamic phosphorylation of synaptic CaMKIIα and MAPK/ErK, Ogundele , Olalekan; Rosa, Fernando; Lee, Charles; Francis, Joseph; Dharmakumar, Rohan, 2017, Frontiers in Neuroscience , Volume: 11, Pages: 447