Chao-Po Lin

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Experts in Genetics

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Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China

Professor Genetics

Biography

1994.9-1998.6 B.S. in the Department of Zoology, National Taiwan University. 2000.9-2002.6 M.S. in the Institute of Genetics, National Yang-Ming University. 2002.9-2003.8 Research assistant, Institute of Microbiology, National Taiwan University College of Medicine. 2003.9-2010.1 Ph.D. in the Department of Pharmacology, Rutgers University, USA. 2010.4-2017.3 Postdoctoral fellow, University of California at Berkeley, USA. 2007.6-now Assistant Professor, PI, ShanghaiTech Uninversity, China

Research Intrest

Our group is interested in the function(s) of microRNAs in pluripotent stem cells, as well as the function(s) of retrotransposons in mammalian development. First, we explore the importance of the p53-microRNA axis in somatic reprogramming, or the generation of induced pluripotent stem cells (iPSCs). Second, we study the roles of microRNAs in modulating the totipotent-like cell fate potential in pluripotent stem cells, a novel potency state of pluripotent stem cells we identified recently (Science, 2017). Finally, we investigate the functional roles of retrotransposons during mammalian pre-implantation and post-implantation development.

List of Publications

Choi YJ, Lin CP, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)

Lin CP, Choi YJ, Hicks GG, and He L. (2011) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle. 11:2063-72

Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, and He L. (2013) A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28(5): 438-50

Choi YJ, Lin CP#, Risso D, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) ( equal contribution; # corresponding author)

1. Lin CP and He L. (2017) Noncoding RNAs in Cancer Development. Annual Reviews of Cancer Biology. 1:163-84.

Experts in China

Zhang Xuming Luo Guoqing Wang Tieguan Wei Zhang Zhao Zhidong Li Lihua Xue Lingyun Lai Liangxue Zhenning Wang Li Dujuan HE CHUN Wei Huachen Xu Ying Wei Minjie Chen Kai Xin Zhang town Lin Shuisheng Guo benqing Yang yong Jia Haitao JIANG Ning Li Qiang Rang-Rong Chang Wang Jian Liu Li Ming View More

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Experts in Genetics

Chao-Po Lin

Choi YJ, Lin CP, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)

Lin CP, Choi YJ, Hicks GG, and He L. (2011) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle. 11:2063-72

Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, and He L. (2013) A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28(5): 438-50

Choi YJ, Lin CP#, Risso D, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) ( equal contribution; # corresponding author)

1. Lin CP and He L. (2017) Noncoding RNAs in Cancer Development. Annual Reviews of Cancer Biology. 1:163-84.

Experts in China

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Experts in Genetics

Chao-Po Lin

Choi YJ*, Lin CP*, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)

Lin CP, Choi YJ, Hicks GG, and He L. (2011) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle. 11:2063-72

Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, and He L. (2013) A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28(5): 438-50

Choi YJ*, Lin CP*#, Risso D*, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) (* equal contribution; # corresponding author)

1. Lin CP and He L. (2017) Noncoding RNAs in Cancer Development. Annual Reviews of Cancer Biology. 1:163-84.

Experts in China

Choi YJ, Lin CP, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)

Choi YJ, Lin CP#, Risso D, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) ( equal contribution; # corresponding author)