Chad Quarles

Associate Professor
Imaging Research
Barrow Neurological Institute
United States of America

Professor Neurology
Biography

Chad Quarles, PhD, earned his undergraduate degree in biophysics at Centenary College of Louisiana in 1999 and his doctorate in biophysics at the Medical College of Wisconsin in 2004. He completed a postdoctoral fellowship in cancer imaging at Vanderbilt University Medical Center in 2006. Dr. Quarles stayed at Vanderbilt and attained the academic rank of associate professor in the Department of Radiology and the Vanderbilt University Institute of Imaging Science. He joined the faculty at Barrow in 2015.. He has a particular interest in leveraging all aspects of imaging science, including image acquisition and formation, contrast mechanisms, and image analysis, to discover novel imaging metrics and expand the clinical utility of bioimaging techniques. When applied to brain cancer imaging, this philosophy has yielded more robust pulse sequences and postprocessing strategies for clinical perfusion imaging, a more comprehensive characterization of contrast agent induced susceptibility effects, and the new MR-based cytographic imaging technique. Dr. Quarles’s research has been continuously funded through multiple grants from the National Institutes of Health and the Department of Defense. At the national level, he is involved with initiatives (e.g. the Quantitative Imaging Network, the Quantitative Imaging Biomarkers Alliance, and the National Brain Tumor Society) that aim to standardize brain cancer imaging acquisition and analysis methods for clinical trials.

Research Intrest

Image-based Biomarkers in Brain Tumors and Alzheimer’s Disease, Digital Reference Objects, MRI Cytography,

List of Publications
1. Stokes AM, Semmineh N, Quarles CC. Validation of a T1 and T2* leakage correction method based on multiecho dynamic susceptibility contrast MRI using MION as a reference standard. Magnetic resonance in medicine. 2016 Aug 1;76(2):613-25.
2. Semmineh NB, Xu J, Skinner JT, Xie J, Li H, Ayers G, Quarles CC. Assessing tumor cytoarchitecture using multiecho DSC‐MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE). Magnetic resonance in medicine. 2015 Sep 1;74(3):772-84.
3. Stokes AM, Quarles CC. A simplified spin and gradient echo approach for brain tumor perfusion imaging. Magnetic resonance in medicine. 2016 Jan 1;75(1):356-62.