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Experts in Pathology
Dr. Sajjan Singh Surana Mahua Choudhury Joseph C. Gregorek Mireya correa Cory Abate-Shen Rosanna G. Abellar Abdul Samad Dr. Ahmed MagdyMetwallyAbd Al Hamid Ester Ballana Guix Jianguo (Jeff) Xia Jen Ronholm David Murdoch Peter D Canoll Susan Best Ryan Blaedow Sofia Avnet Lucio Montanaro Lynn K Carta Kurian P. Abraham Dr Gavin Hunter View MoreCarol de la Motte
Staff
Pathobiology
Cleveland Clinic Lerner Research Institute
United States of America
Our laboratory focuses innate mechanisms of intestinal protection that when dysregulated lead to disease. Our research focuses on hyaluronan (HA) as a key molecule that mediates the mechanisms, and how, when dysregulated, can lead to disease.
The etiology of inflammatory bowel disease (IBD), similar to many other inflammatory diseases, is unknown, no doubt because multiple factors are at play to initiate, drive and sustain immune responses. Hyaluronan (HA), an extracellular matrix component, is increased in inflamed human colon during flares of IBD and in animal models of colitis, where it precedes leukocyte infiltration.