Carlos E. Mendoza Santiesteban

Assistant Professor of Clinical Ophthalmology
Clinical Ophthalmology
Bascom Palmer Eye Institute
United States of America

Professor Ophthalmology
Biography

Dr. Mendoza field of work includes adult and pediatric clinical neuro-ophthalmology and medical retina, with special interest in diagnostic tools such as visual electrophysiology and retinal imaging. He has been working in these areas for more than 20 years. He was trained as medical doctor, neuro-physiology resident, second degree ophthalmology resident, medical retina/electrophysiology fellow and neuro-ophthalmology fellow. He received additional post-graduate training courses in Germany, Italy and Japan. He was director of visual electrophysiology unit at the Institute of Neurology and Neurosurgery, Havana, Cuba, and later director of neuro-ophthalmolgy at the Cuban Institute of Ophthalmology. From 2013-2016 he served as medical director of the visual electrophysiology unit at the New England Eye Center, Tufts University, Boston, Massachusttes, USA. His early works were about the use of visual electrophysiology in the diagnosis of eye and brain diseases, showing the role of the electroretinogram and visual evoked potentials in the study of several optic neuropathies and retinopathies. He paid special interest to the Cuban epidemic optic neuropathy (CEON) which affected more tan 50 000 cubans in the early 1990s. He compared the similitudes between CEON and Leber Hereditary Optic Neuropathy (LHON) and with his group, postulated the mitochondrial origin of the CEON. During his residencies he started get interested in a newly developed eye imaging technology to study the retinal structure. Optical coherence tomography (OCT) was a major breakthrough in ophthalmology and has been a technological core of many of his research projects during the last 18 years. He was part of an international team that build the first normative database for the retinal nerve fiber layer thickness. As director of the neuro-ophthalmology service at the Cuban Institute of Ophthalmology he developed several research projects in conjunction with international academic institutions about the use of OCT, microperimetry, and visual electrophysiology in the diagnosis of several types of optic neuropathies and retinopathies. During that period he also published results about orbital tumors surgery using minimally invasive approaches

Research Intrest

The Eye in Familial Dysautonomia. Retinal Biomarkers of Neurological Diseases (Parkinson’s Disease, Multiple Sclerosis, Alzheimer’s Disease, Multiple System Atrophy). Hereditary Optic Neuropathies. Retinal and Optic Nerve Imaging. Hydroxichloroquine Retinal Toxicity. Hereditary Retinal Diseases. Visual Electrophysiology. Neuro-Ophthalmology.

List of Publications
Mendoza-Santiesteban CE, Palma JA, Norcliffe-Kaufmann L, Kaufmann H. Familial dysautonomia: a disease with hidden tears. Journal of Neurology. 2017 Apr 11:1-2.
Mendoza-Santiesteban CE, Palma JA, Ortuño-Lizarán I, Cuenca N, Kaufmann H. Pathologic confirmation of retinal ganglion cell loss in multiple system atrophy. Neurology. 2017 Jun 6;88(23):2233-5.
Mendoza-Santiesteban CE, Gabilondo I, Palma JA, Norcliffe-Kaufmann L, Kaufmann H. The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis. Frontiers in neurology. 2017;8.