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Bruce Palmer Bean

Professor
Departmaent of Neurobiology
Harvard Medical School
United States of America

Professor Medical Sciences
Biography

Our research is directed at understanding electrical signaling in the brain. Information in the brain is encoded as patterns of "action potentials", brief (~ 1 millsecond) reversals of the voltage across the membrane of neurons. Different neurons in the brain fire action potentials with a wide variety of distinct patterns. We seek to understand the different patterns of firing in terms of the underlying molecular devices - tiny pores in the membrane known as ion channels. In mammalian brains, each neuron possesses several dozen different types of ion channels. Most of these are closed when the neuron is at rest (electrically silent), and it is the coordinated, transient opening ("gating") of particular types of ion channels that underlies electrical signaling.

Research Intrest

Pharmacological agents Including antiepileptic drugs Interact with voltage-dependent channels Pharmacology of ion channels To generate ultra-rapid electrical signaling.    

List of Publications
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3.
Inhibition of A-type potassium current by the peptide toxin SNX-482. Kimm T, Bean BP. J Neurosci. 2014 Jul 9;34(28):9182-9. doi: 10.1523/JNEUROSCI.0339-14.2014.
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.
Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing. Yamada-Hanff J, Bean BP. J Neurophysiol. 2015 Oct;114(4):2376-89. doi: 10.1152/jn.00489.2015. Epub 2015 Aug 19.
Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons. Kimm T, Khaliq ZM, Bean BP. J Neurosci. 2015 Dec 16;35(50):16404-17. doi: 10.1523/JNEUROSCI.5291-14.2015.
Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Elife. 2016 Apr 13;5. pii: e15751. doi: 10.7554/eLife.15751.
Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Elife. 2016 Apr 13;5. pii: e15751. doi: 10.7554/eLife.15751.
Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States. Jo S, Bean BP. Mol Pharmacol. 2017 Apr;91(4):277-286. doi: 10.1124/mol.116.106401. Epub 2017 Jan 24.
Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Gantz SC, Bean BP. Neuron. 2017 Mar 22;93(6):1375-1387.e2. doi: 10.1016/j.neuron.2017.02.025. Epub 2017 Mar 2.
Breaking barriers to novel analgesic drug development. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Nat Rev Drug Discov. 2017 Aug;16(8):545-564. doi: 10.1038/nrd.2017.87. Epub 2017 Jun 9. Review.

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