Brian D Brown

Associate Professor
Genetics and Genomic Sciences
Mount Sinai School of Medicine
United States of America

Professor Genetics
Biography

Dr. Brian Brown is broadly trained in molecular and cellular biology with a strong focus on immunology and translational medicine. His training began with his doctoral studies in Canada and his work with hematologist Dr. David Lillicrap and virologist Dr. Frank Graham to establish ways to overcome the immune response hindering gene therapy. He subsequently did his postdoctoral studies in Italy under the supervision of Drs. Luigi Naldini and Maria Grazia Roncarolo, leaders in molecular medicine and immunology. There, he helped develop a new platform for controlling gene expression, which has led to improvements in experimental treatments for genetic disease, cancer, and viral infection. In 2008 Dr. Brown joined the faculty of Mount Sinai as an Assistant Professor and he was promoted to Associate Professor in 2013.

Research Intrest

Antigen Presentation, Autoimmunity, Cell Biology, Cellular Immunity, Dendritic Cells, Diabetes, Gene Discovery, Gene Expressions, Gene Regulation, Gene Therapy, Immunological Tolerance, Immunology, Infectious Disease, Inflammation, Macrophage, Molecular Biology, RNA, RNA Splicing & Processing, Retrovirus, T Cells, Tolerance, Transcriptional Activation and Repression, Transgenic Mice

List of Publications
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, etal (2013) The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nature Immunology.
Israelow B *, Mullokandov G *, Agudo J, Sourisseau M, Bashir A, etal (2014) Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors. Nature Communications 5: 5408.
Kidd BA *, Wroblewska A *, Boland MR, Agudo J, Merad M, etal (2016) Mapping the effects of drugs on the immune system. Nature Biotechnology 34: 47-54.
Agudo J, Ruzo A, Park ES, Sweeney R, Kana V, etal (2015) GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions. Nature Biotechnology 33: 1287-1292.
Brown BD, Merad M (2015) Authorship: Archives and citation miss equal authors. Nature 528: 7582.