Bill Meek

Professor
Anatomy & Cell Biology
Oklahoma State University Medical Center
United States of America

Professor Cardiology
Biography

I joined the faculty of the OSU College of Osteopathic Medicine anatomy department following postdoctoral fellowships at the Eleanor Roosevelt Institute for Cancer Research in Denver, Colorado, and the Molecular, Cellular, and Developmental Biology Department at the University of Colorado in Boulder, Colorado. With this background I was interested in the mechanisms of cell biology and the microscopic anatomy of the cell and its application to the cancer cell and genetic diseases. I was trained in the area of electron microscopy and cell culture and thus worked extensively in these two fields to investigate the structure of the cell during the "early" days of scanning electron microscopy and high voltage electron microscopy. I feel privileged to have worked as the advisee of two pioneers in the areas of cell culture and electron microscopy, Ted Puck and Keith Porter. At the time of my postdoctoral study, the structural nature of the cell was beginning to unfold with the advancement of viewing techniques in the areas of immunology and microscopy. These applications were also being applied to learning more about the metastatic properties of cancer cells. My training was firmly grounded in gross anatomy and the anatomy discipline in general, as I assisted with teaching during my graduate studies at the Baylor University Medical Center in Dallas.

Research Intrest

My research interest is in the area of the cytoskeleton and its relationship to developmental and cellular functions. Current projects include the arrangement of vimentin intermediate filament network in epithelial cells, fine structural studies of flagellar length control and flagellar movement, and morphological assessment of a skin explant model in metastasis and dermal interaction.

List of Publications
Meek WD, Porter KR, Puck TT. The ultrastructure of process formation following treatment with db-cAMP of a Chinese hamster ovary x Chinese hamster brain cell hybrid. Experimental cell research. 1980 Apr 1;126(2):359-74.
Meek WD, Raber BT, McClain OM, McCosh JK, Baker BB. Fine structure of the human synovial lining cell in osteoarthritis: its prominent cytoskeleton. The Anatomical Record. 1991 Oct 1;231(2):145-55.
Meek WD, Puck TT. Role of the microfibrillar system in knob action of transformed cells. Journal of Cellular Biochemistry. 1979 Jan 1;12(3):335-54.